Registration Dossier
Registration Dossier
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EC number: 219-292-8 | CAS number: 2403-89-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- sub-chronic toxicity: oral
- Type of information:
- other: OECD Toolbox v3.4 read across study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 422 (Combined Repeated Dose Toxicity Study with the Reproduction / Developmental Toxicity Screening Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
- EC Number:
- 219-292-8
- EC Name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
- Cas Number:
- 2403-89-6
- Molecular formula:
- C10H21NO
- IUPAC Name:
- 1,2,2,6,6-pentamethylpiperidin-4-ol
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 63d
- Frequency of treatment:
- daily
Results and discussion
Effect levels
- Dose descriptor:
- NOEL
- Effect level:
- 226 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: not specified
- Remarks on result:
- other: OECD TG422 test
- Remarks:
- 95% confidence 58.4-871)
Target system / organ toxicity
- Critical effects observed:
- no
Applicant's summary and conclusion
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