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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Study period:
1986
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study was conducted according to an appropriate OECD test guideline. It was not compliant with GLP.

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1992

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Nonan-1-ol
EC Number:
205-583-7
EC Name:
Nonan-1-ol
Cas Number:
143-08-8
Molecular formula:
C9H20O
IUPAC Name:
nonan-1-ol
Details on test material:
No data.

Test animals

Species:
rabbit
Strain:
New Zealand White
Details on test animals or test system and environmental conditions:
No data.

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
other: undiluted (and as 50% solution in PEG400)
Controls:
not specified
Amount / concentration applied:
TEST MATERIAL

- Concentration (if solution): Undiluted or 50% in PEG.
Duration of treatment / exposure:
4 hour(s)
Observation period:
72 hours
Number of animals:
6
Details on study design:
TEST SITE

- Application under exposure chamber of 6cm2.

REMOVAL OF TEST SUBSTANCE

-Not reported.

SCORING SYSTEM: Draize

Results and discussion

In vivo

Irritant / corrosive response data:
See table 1 and 2.
Other effects:
None reported.

Any other information on results incl. tables

Table 1: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test. Undiluted test substance.

Score at time point / Reversibility

Erythema

Edema

Max. score: 4

Max. score: 2

60 min (group mean)

0.8

0

24 h (group mean)

 1.8

0

48 h (group mean)

 2.4

0

72 h (group mean)

 2.4

0

Average 24h, 48h, 72h

 2.2

0

Reversibility*)

Average time (unit) for reversion

 -

*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible#

Table 2: Irritant/corrosive response data for each animal at each observation time up to removal of each animal from the test. 50%nonanolin PEG400.

Score at time point / Reversibility

Erythema

Edema

Max. score: 4

Max. score: 2

60 min (group mean)

0.8

0.2

24 h (group mean)

 1.8

0.2

48 h (group mean)

 2.0

0.4

72 h (group mean)

 2.0

0

Average 24h, 48h, 72h

 1.9

0.2

Reversibility*)

Average time (unit) for reversion

 -

 

*) Reversibility: c. = completely reversible; n.c. = not completely reversible; n. = not reversible

 (individual animal scores were not reported)

 

 

Applicant's summary and conclusion

Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
A mean erythema score of 2.2 was determined in a reliable study conducted according to an appropriate test protocol. The study was not in compliance with GLP.