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Physical & Chemical properties

Partition coefficient

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Description of key information

The measured partition coefficient of tert-Butylamine the hydrolysis product of tert.-Butylisocyanate is LogPow = 0.40.

Key value for chemical safety assessment

Log Kow (Log Pow):
0.4

Additional information

The calculated partition coefficient of tert.-Butylisocyanate is accounts for logPow = 2.15 (Currenta, 2011). Tert.-Butylisocyanate hydrolyzes rapidly under the formation of the crresponding amine, therefore the value is only of theoretical interest.

Read-Across-Justification:

Isocyanates are known to rapidly hydrolyse under the formation of the corresponding amine as well as solid polyurea compounds *. However, the insoluble inert polyurea is not assumed to cause environmental hazards due to the reduced uptake of high molecular mass compounds, whereas the amine is assumed to be the ecotoxicological relevant species. Concluding, tests performed using the corresponding amine can equally be used to assess the ecotoxicological hazards of isocyanates assuming the complete transfer of the isocyanate into the corresponding amine while neglecting the formation of a certain fraction ecotoxicological not active polyurea com-pounds. An underestimation of environmental hazards is thus avoided supporting a conservative and thus protective hazard assessment.

* Test Lab (2004). 4-chlorophenyl-isocyanate: Investigation on Stability in Aqueous Test Solutions. Project No: 200300181.

* Test Lab (2003). Isopropylisocyante: Investigation on Stability in Aqueous Test Solutions. Project No: 200300095.