Registration Dossier
Registration Dossier
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EC number: 216-544-9 | CAS number: 1609-86-5
Endpoint summary
Administrative data
Description of key information
In a valid oral toxicity study a LD50 = 185 mg/kg bw for rats (male) was found
2 acute inhalation toxicity studies are available:
In the key study according OECD 403 for male + female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found. In an inhalation-hazard test rats were placed in a 10 l glass chamber and were exposed whole body for 3 or 10 min to the vapour of tert-butylisocyanate and were observed for 14 d after the exposure to the test substance. 3 min. exposure: 5/5 males died within 4 minutes after start of exposure; 4/5 females died within 6-12 minutes after start of exposure, signs of irritation were found; 10 min.exposure: all rats died within 4 minutes after start of exposure, signs of irritation were found.
No study was available for acute dermal toxicity.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 185 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 1 593 mg/m³ air
Additional information
In a reliable oral toxicity studies a LD50 of 185 mg/kg bw on male rats were found.
In a guideline study according OECD 403 for male and female rats a LC50 = 1593 mg/m³ air (analytical vapour concentration) was found.
For acute dermal toxicty no data were available.
Justification for classification or non-classification
For the acute oral toxicity a classification as T, R25 justified as a result of the LD50 = 185 mg/kg bw
For the acute inhalation toxicity T, R23 is justified as a result of the LC50 = 1593 mg/m³ air
In addition, respiration irritational effects were reported. Therefore R 37 is applicable
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