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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

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Diss Factsheets

Toxicological information

Skin irritation / corrosion

Currently viewing:

Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
guideline study without detailed documentation

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1987
Report date:
1987

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Ferrocene
EC Number:
203-039-3
EC Name:
Ferrocene
Cas Number:
102-54-5
Molecular formula:
C10H10Fe
IUPAC Name:
iron(2+) dicyclopenta-2,4-dienide

Test animals

Species:
rabbit
Strain:
other: White Russian
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: dr. Karl.Thomae GmbH, Biberach
- Weight at study initiation: 2.1-2.8kg
- Diet:ad libitum
- Water: ad libitum
- Acclimation period: 14days
- Sex: male

ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20+-1
- Humidity (%): 60+-5
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12

Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
0.5g
Duration of treatment / exposure:
4 hours then patch removed
Observation period:
3 days
Number of animals:
3

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
primary dermal irritation index (PDII)
Basis:
mean
Time point:
other: 72 hours
Score:
0.5
Max. score:
1
Reversibility:
fully reversible within: 6 days
Irritation parameter:
erythema score
Basis:
mean
Time point:
24/48/72 h
Score:
0.56
Max. score:
2
Reversibility:
fully reversible within: 6 days
Irritation parameter:
edema score
Basis:
mean
Time point:
24/48/72 h
Score:
0
Max. score:
0

Applicant's summary and conclusion

Interpretation of results:
GHS criteria not met
Conclusions:
In a Study performed to OECD Guideline 404, Ferrocene on the skin of male rabbits is a non-irritant. This is based on the primary dermal irritation index value of 0.5