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Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study well documented, meets generally accepted scientific principles, acceptable for assessment.

Data source

Reference
Reference Type:
publication
Title:
Studies in detoxication 46 The metabolism of aliphatic alcohols. The glucuronic acid conjugation of acyclic aliphatic alcohols.
Author:
Kamil I A et al
Year:
1953
Bibliographic source:
Biochem 53:129-136

Materials and methods

Principles of method if other than guideline:
These studies were carried out to determine the extent to which various monohydric aliphatic alcohols, including C6-C18 alcohols included in this
category, form glucuronic acid conjugates in the rabbit. The excretion of glucuronic acids was determined daily in the urine for a week prior to administration of the test compound to establish a base line. Following dosing the urine was collected for 24 hours and the glucuronides extracted. The results were reported as the amount of extra glucuronic acid excreted as a % of dose.

Test material

Constituent 1
Chemical structure
Reference substance name:
Hexan-1-ol
EC Number:
203-852-3
EC Name:
Hexan-1-ol
Cas Number:
111-27-3
Molecular formula:
C6H14O
IUPAC Name:
hexan-1-ol

Test animals

Species:
rabbit
Strain:
Chinchilla

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Duration and frequency of treatment / exposure:
One dose
Doses / concentrations
Remarks:
Doses / Concentrations:
25 mmoles/rabbit
No. of animals per sex per dose / concentration:
3

Results and discussion

Metabolite characterisation studies

Metabolites identified:
yes
Details on metabolites:
All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose. For hexan-1-ol this was 10.3% glucuronic acid excreted as % of dose (average of 3 rabbits).

Any other information on results incl. tables

The extra glucuronide excreted as % of dose (average of 3 rabbits, 2 rabbits for *) was as follows:

n-hexanol 10.3%; n-heptanol 5.3%; n-octanol 9.5%; n-nonanol 4.1%;  n-decanol* 3.5%; n-octadecanol* 7.6%. It was reported that absorpton of 

n-decanol and n-octadecanol was incomplete and irregular and the alcohol could be isolated in quantity from the faeces.

No further information on other biotransformation pathways of these alcohols was provided.

Applicant's summary and conclusion

Conclusions:
Interpretation of results: no bioaccumulation potential based on study results
All the primary alcohols investigated form glucuronic acid conjugates which are excreted in the urine. However this was generally <10% of the dose.