Registration Dossier
Registration Dossier
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 200-456-2 | CAS number: 60-12-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1987
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 987
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Phenylethyl alcohol
- IUPAC Name:
- Phenylethyl alcohol
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Sgarlat's Rabbitry, Harvey's Lake, Pennsylvania
- Age at study initiation:
- Weight at study initiation: 2-3 kilograms
- Fasting period before study:
- Housing: individual cages sized in accordance with the Guide for the Care and Use of Laboratory Animals of the Institute of Laboratory Resources, national research Council
- Diet (e.g. ad libitum): Wayne Rabbit Ration, ad libitum
- Food analysis: there were no contaminants
- Water (e.g. ad libitum): Fresh tap water, fit for human consumption was available ad libitum, using 16 ounce glass bottles with rubber stopper and stainless steel sipper tube or an automatic watering system supplied by Edstrom Indistries Inc. Waterford, Wisconsin.
- Acclimation period: 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20°C+/- 3°C
- Humidity (%): 30-70%:
- Photoperiod (hrs dark / hrs light): 12 hrs light/ 12 hrs night
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: administred as received
- Duration of exposure:
- 24 hrs
- Doses:
- 2000 mg/kg (Limit Test)
1600, 2500, 4000 mg/kg - No. of animals per sex per dose:
- Total: 10
Male: 5
Female: 5 - Details on study design:
- Pre-test
The trunk of the animals was shaved in order to have at least 10% (about 240 cm) of the dorsal body surface area available for application of the test material. Immidiately prior dosing, the skin of five males and five females for the 2000 mg/kg limit test and the skin of 2 males and 2 females pr group for the definitive LD50 determination was abraded by making four epidermal incisions with a clean needle to produce bleeding. The test material was applied directly onto the exposed skin of the animals. A layer of gauze was wrapped around the animals to cover the dosed area. The animal was wrapped with rubber dam and an Ace bandage to retard evaporation. The test article was held in contact with the skin of the animals for 24-hrs. After that, the test site was washed to remove any remaining material.
Observations:
Observation were recorded at 2 and 4 hrs after the 24 hrs period of exposure and twice daily thereafter for 14 days. Body weights were recorded weekly and at the study termination. All rabbits were sacrificed by CO2 inhalation od Day 14 and a gross necropsy was performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 535 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 769 - 3 634
- Remarks on result:
- other: One of 8 animals died at 1600 mg/kg level, 5 of 8 died at 2500 mg/kg and 6 of 8 died at 4000 mg/kg.
- Mortality:
- Six of the 10 animals died at 2000 mg/kg. One of the eight animals died at the 1600 mg/kg level, five of eight died at 2500 mg/kg and six of eight died at 4000 mg/kg.
- Clinical signs:
- other: Signs observed at 2000 mg/kg/day are: diarrhea, semi-prostation, body drop, prostation, abnormal gait, decreased activity and abnormal stance. Signs observed at the 1600, 2500 and 4000 mg/kg levels included: erythema, body drop, decreased activity, decrea
- Other findings:
- Necropsy of those animals dying on study revelead discolored adrenals and hemorrhages present in the muscle underlying the application site. Necropsy of animals exposed to 1600 mg/kg level, 2500 mg/kg and 4000 mg/kg revealed hemorrhages on muscle underlying the application site and dark fluid present in the bladder. Dried exudate around the oral and nasal cavities was also observed.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Based upon the observation made in the acute dermal toxicity test in rabbits, the estimated acute dermal LD50 for phenylethyl alcohol was considered to be 2535 mg/kg with 95% confidence limits of 1769 to 3634 mg/kg.
- Executive summary:
The acute dermal toxicity potential of phenylethyl alcohol was investigated using 3 groups of 8 rabbits (4 males and 4 females). The test item was administrated at dose levels of 1600, 2500 and 4000 mg/kg. At all dosage levels the main signs observed were prostration, decreased activity, which disappeared after 4 -5 days from the treatment. Mortaility occurred for 1 of the 8 animals exposed to 1600 mg/kg, and for 6 of 10 animals exposed to 2000 mg/kg for 5 of 8 animals treated with 2500 mg/kg and for 6 of 8 rabbits treated with 4000 mg/kg. In conclusion, the estimated acute dermal LD50 of phenylethyl alcohol was considered to be 2535 mg/kg with 95% confidence limits of 1769 to 3634 mg/kg, under the condition of the study.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
