Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 261-605-5 | CAS number: 59113-36-9
Endpoint summary
Administrative data
Description of key information
A reliable oral toxicity study in rats (according to OECD 401) with diglycerol has been performed showing an LD50 > 5000 mg/kg bw. A second oral toxicity study in rats (according to OECD 401) with cyclic diglycerol also showed an LD50 > 2000 mg/kg bw. No studies on acute exposure via inhalation or skin are available. A dermal toxicity study performed with glycerol was performed, showing an LD50>2000 mg/kg.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 5 000 mg/kg bw
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 18 700 mg/kg bw
Additional information
In a limit test (key study) performed according to OECD 401 and GLP, the LD50 of the substance was found to exceed 5000 mg/kg bw. No mortalities or signs of intoxication were observed. No adverse effects on bodyweight and no abnormalities at necropsy were noted. This was supported by a limit study in which the LD50 of cyclic diglycerol was determined to exceed 2000 mg/kg bw. No mortalities or signs of intoxication were observed. No adverse effects on bodyweight and no abnormalities at necropsy were noted.
Acute dermal toxicity was read-across from glycerol. After 8 hour exposure to 6.25 - 18.7 g/kg b.w. glycerin, no deaths occurred in a group of 6 rabbits after occlusive dermal application. No effects of acute toxicity were observed. The LD50 is determined to be >18.7 g/kg b.w.
Justification for classification or non-classification
Based on the available data, diglycerol does not have to be classified for acute oral and dermal toxicity according to CLP Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
