Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: other routes

Currently viewing:

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1979
Report date:
1979

Materials and methods

Principles of method if other than guideline:
BASF Test: The substance was injected into the peritoneal cavity of mice. One group of 5 mice per sex was treated with a preparation of the test substance in 0.5% CMC at a dose of 200 mg/kg bodyweight. The volume per kg body weight was 10 ml. Documentation of clinical signs was performed over the 14-day study period.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-(dimethylamino)ethyl acrylate
EC Number:
219-460-0
EC Name:
2-(dimethylamino)ethyl acrylate
Cas Number:
2439-35-2
Molecular formula:
C7H13NO2
IUPAC Name:
2-(dimethylamino)ethyl acrylate
Details on test material:
- Name of test material (as cited in study report): Dimethylaminoethylacrylat
- Purity: > 90 %

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Wiga, Sulzfeld, FRG
- Weight at study initiation: mean males: 28 g; mean females: 22 g
- Fasting period before study: 15 - 20 hours before application
- Diet: Herilan MRH-Haltung (H. Eggersmann KG)

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
ADMINISTRATION VOLUME: 10 ml/kg bw
Doses:
200 mg/kg bw
No. of animals per sex per dose:
5
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
ca. 200 mg/kg bw
Mortality:
Males: 2/5; females: 3/5
Clinical signs:
Dyspnoea, apathy, staggering, scrubby fur, clotted eyes, bad general state.
Gross pathology:
Animals that died and sacrificed animals: No intraabdominal precipitation or agglutination of the test substance.

Any other information on results incl. tables

Mortality data:

 

No. dead / No. dosed

Time after administration

Males

Females

Total

1 h

0/5

0/5

0/10

1 d

0/5

0/5

0/10

2 d

1/5

1/5

2/10

7 d

2/5

3/5

5/10

14 d

2/5

3/5

5/10

 

Mean body weight data:

Time

Males

Females

Start of study

28

22

2-4 d

25.0

18.4

7 d

29.4

20.0

13 d

34.0

23.0

Applicant's summary and conclusion

Categories Display