Registration Dossier
Registration Dossier
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EC number: 233-560-1 | CAS number: 10233-13-3
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on microorganisms were observed at the highest test concentration
Key value for chemical safety assessment
Additional information
There are no studies available on the toxicity of Isopropyl laurate (CAS 10233-13-3) to microorganisms. The assessment of was therefore based on studies conducted with the structurally most similar category members, for which data is available Isopropyl myristate (CAS 110-27-0) and Isopropyl oleate (CAS 112 -11-8), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
In the key study conducted with Isopropyl myristate (CAS 110-27-0), the acute toxicity to Pseudomonas putida was tested according to a national guideline and GLP (Coenen 1988). Nominal test substance concentrations ranged from 0.004 to 18 mg/L. After an incubation time of 18 hours, no real toxicity threshold could be determined, since all the measured extinction values were very close to the reference. Therefore an EC50(18h) > 10 mg/L according to the estimated limit of water solubility was stated.
The study conducted with Isopropyl oleate (CAS 112 -11-8) was used to gain supportive information. In a GLP-guideline study according to ISO 10712, the growth inhibition of Pseudomonas putida was tested, using a water soluble fraction of 10000 mg/L nominal loading. The EC50(16h) was established as >10000 mg/L (Mead 1997).
Thus, based on the above mentioned result, and due to the structural and profile similarities of the two substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on microorganisms are expected for Isopropyl laurate (CAS 10233 -13 -3).
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