Registration Dossier
Registration Dossier
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EC number: 205-563-8 | CAS number: 142-82-5
Specific investigations: other studies
Administrative data
- Endpoint:
- specific investigations: other studies
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1982
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Basic data given (comparable to standards). Vapour generation and analysis not well documented.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
- Principles of method if other than guideline:
- Respiratory tract irritancy determined by measuring the degree of sensory irritation.
- GLP compliance:
- no
- Type of method:
- in vivo
- Endpoint addressed:
- respiratory irritation
Test material
- Reference substance name:
- Heptane
- EC Number:
- 205-563-8
- EC Name:
- Heptane
- Cas Number:
- 142-82-5
- Molecular formula:
- C7H16
- IUPAC Name:
- heptane
- Details on test material:
- - Name of test material (as cited in study report): n-heptane
- Analytical purity: 100% pure commercial product
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River
Administration / exposure
- Route of administration:
- inhalation: vapour
- Vehicle:
- unchanged (no vehicle)
- Details on exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: head only exposure chamber
- Source and rate of air: room air - Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 2 treatments of 1 minute with 10 minute non-treatment period between each treatment.
- Frequency of treatment:
- once
- Post exposure period:
- none
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
81.9 mg/L (re-calculated; corresponding to 20000 ppm)
Basis:
analytical conc.
- Remarks:
- Doses / Concentrations:
29.29 mg/L
Basis:
nominal conc.
- No. of animals per sex per dose:
- 4 males
- Control animals:
- other: each animal established control breathing pattern prior to treatment by exposure to room air
Results and discussion
- Details on results:
- No graphic patterns indicative of respiratory pauses were evident throughout the exposures.
Applicant's summary and conclusion
- Conclusions:
- Based on these results, exposure to Normal-Heptane at a nominal and analytical concentrations of 29.29 and 81.9 mg/L of air via inhalation, respectively, failed to produce respiratory irritancy in mice.
- Executive summary:
Based on these results, exposure to Normal-Heptane at a nominal and analytical concentrations of 29.29 and 81.9 mg/L of air via inhalation, respectively, failed to produce respiratory irritancy in mice.
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