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EC number: 258-207-9 | CAS number: 52829-07-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
The test substance is expected to be absorbed to some extent in the rat and dog, distributed, metabolized and excreted with no indication of accumulation.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
The following prediction for the metabolic fate of the test substance can be made: The test substance has amphiphilic properties and is expected to be well absorbed from the gastrointestinal tract and consequently bioavailable to some extent. Metabolic degradation of Phase I hydrolysis is assumed, generating 2,2,6,6-Tetramethylpiperidin-4-ol (HTMP) and sebacic acid (decanedioic acid) as the main metabolites, leading to phase II reactions and rapid urinary and/or biliary elimination.
The metabolite HTMP showed much less affinity to Ca-channel and acetylcholine receptors than the parent compound. This is reflected the absence of cardio-/neurotoxicity after oral administration in contrast to parenteral treatment or in-vitro study designs [1, 2].
This prediction is in line with the results of the acute toxicity studies in rats and repeat-dose toxicology studies in both rats and dogs showing low acute toxicity and absence of relevant findings after repeated administration in clinical pathology and post mortem examinations. In dogs only, hepatocellular hypertrophy of a minimal degree was observed. In rats deaths occurred at excessive dosages of ≥ 600 mg/kg, accompanied by clinical signs of poor general condition, that in single cases could also be interpreted as signs of neurotoxicity. All other findings seen can be attributed to palatability problems in the in-feed studies in rats and dogs.
1. Glossmann H et al. (1993) Proc. Nat. Acad. Sci. USA, Vol 90, 9523 -9527
2. Sotonyi P et al. (2004) Tox. Sciences 77, 368 -374
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