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Boiling point

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Reference
Endpoint:
boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-07-14 to 2003-07-15
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 103 (Boiling point/boiling range)
Version / remarks:
27 July 1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.2 (Boiling Temperature)
Version / remarks:
December 1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
differential scanning calorimetry
Key result
Boiling pt.:
222.1 °C
Atm. press.:
97.5 kPa
Remarks on result:
other: ± 2.4 °C
Key result
Boiling pt.:
495.3 K
Atm. press.:
97.5 kPa
Remarks on result:
other: ± 2.4 K

The DSC curve of the preliminary test under nitrogen atmosphere (heating rate if 20 K/min from 25°C to 400°C) is shown in Figure 1 (attached). An endothermic heat effect, the boiling was observed at about 221.2°C. After the experiment, the sample had lost about 99% of its mass and the colour of the sample residue was yellow.

In order to determine the boiling point more precisely, further DSC runs were recorded between 150°C and 350°C with a heating rate of 5 K/min in a nitrogen atmosphere. In the first main test run, the boiling of the test item was detected at 220.3°C. During the second run, the boiling point was determined to be 224.8°C. During these runs, the samples lost 97% and 96% respectively of their mass. After the measurement, the sample residues were coloured yellow. The DSC curve of the first main test run in shown in Figure 2 attached.

The results are shown in the table below.

 Run No. Heating range (°C) Heating rate (K/min)  Boiling point (°C)  Boiling point (K) 
Preliminary Test  25 - 400  20  221.20  494.40 
 1st Main Test 150 - 350 220.28  493.48 
 2nd Main Test 150 - 350  224.79  497.99 
 Mean of boiling point observed:       222.1 ± 2 .4 495.3 ± 2.4 

The boiling point was calculated from the "Onset point" of the endothermic peaks.

The mean boiling point was calculated from the bold values.

Conclusions:
A boiling point value of 222.1 ± 2.4°C at 97.5 kPa was determined in a reliable study conducted according to an appropriate test protocol, and in compliance with GLP. The result is considered to be reliable.

Description of key information

Boiling Point: 222.1°C at 97.5 kPa (OECD 103)

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
222.1 °C

Additional information

A measured boiling point of 222.1°C (495.3 K) at 97.5 kPa was determined for the substance according to OECD Test Guideline 103 and in compliance with GLP. The result is considered to be reliable and is selected as key study.

A limit value of >200°C was reported in a secondary source to which no reliability could be assigned.