Registration Dossier

Guidance on Safe Use

Guidance on Safe Use

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Administrative data

First-aid measures

General: Pay attention to self-protection. Move into fresh air and keep at rest. Consult a physician for specific advice.

Inhalation: Move the exposed person to fresh air at once. When breathing is difficult, properly trained personnel may assist affected person by administering 100% oxygen. Consult a physician for specific advice.
Eye contact: Important! Immediately rinse with water for at least 15 minutes. Call a physician or poison control center immediately.
Skin Contact: Wash off promptly and flush contaminated skin with water. Promptly remove clothing if soaked through and flush skin with water. Call a physician or poison control center immediately. Wash contaminated clothing before reuse.
Ingestion: If swallowed, do NOT induce vomiting. Give a glass of water. Do not give victim anything to drink if he is unconscious. Get medical attention immediately.

Most important symptoms and effects, both acute and delayed:
Aspiration into the lungs may occur during injestion or vomiting, resulting in lung injury and may be fatal. Therefore, emesis should not be induced mechanically or pharmacologically. This product reacts with moisture in the acid contents of the stomach to form methanol. The combination of visual disturbances, metabolic acidosis, and formic acid in the urine is evidence of methanol poisoning. The therapeutic intravenous administration of ethanol (10 ml per hour) allows it to be preferentially oxidized and reduces production of methanol metabolites. Acidosis must be treated by means of intravenous sodium bicarbonate, and methanol elimination may be increased by hemodialysis, as indicated. Treatment should be based on blood methanol levels and acid-base balance. Folates may be administered to enhance the metabolism of formaldehyde. 4-Methyl pyrazole has been suggested as an antidote: because of its alcohol dehydrogenase inhibiting effects, it reduces the production of formate and the development of metabolic acidosis. However, the value of this antidote remains to be proven in humans.

Treatment:
Product may hydrolyze upon contact with body fluids in the gastrointestinal tract to produce additional methanol. The potential for toxic effects due to methanol formation (eye damage and blindness, metabolic acidosis, dizziness and drowsiness, fetal toxicity, and liver, kidney, and heart muscle damage) should be recognized.

Fire-fighting measures

General Fire Hazards: Do not use water jet as an extinguisher, as this will spread the fire. Use water spray to keep fire-exposed containers cool.
Suitable extinguishing media: Alcohol resistant foam. Carbon dioxide Dry chemical.
Unsuitable extinguishing media:
Avoid water in straight hose stream; will scatter and spread fire.
5.2 Special hazards arising from the substance or mixture:
In case of fire, carbon monoxide and carbon dioxide may be formed.
Advice for firefighters/Special fire fighting procedures:
Take precautionary measures against static discharges. To prevent and minimize fire or explosion risk from static accumulation and discharge, effectively bond and/or ground product transfer system.
Special protective equipment for fire-fighters: Wear self-contained breathing apparatus and protective clothing.

Accidental release measures

Personal precautions, protective equipment and emergency procedures:
Avoid contact with eyes, skin, and clothing. Avoid contact with liquid and vapors. Use personal protective equipment.
Environmental Precautions: Prevent runoff from entering drains, sewers, or streams.
Methods and material for containment and cleaning up: Absorb spillage with suitable absorbent material. Shovel up and place in a container for salvage or disposal.
Reference to other sections: Remove sources of ignition. In case of spills, beware of slippery floors and surfaces. See Section Exposure controls/personal protection for Personal Protective Equipment. Collect and dispose of spillage as indicated in section Disposal considerations.

Handling and storage

Precautions for safe handling: Do not taste or swallow. Avoid contact with eyes, skin, and clothing. Avoid breathing mists or vapors. Provide adequate ventilation. Wash hands after handling. See Section Exposure controls/personal protection for Personal Protective Equipment. Workers sensitized to other isocyanates should not handle this material.
Storage conditions: Keep container tightly closed. Keep away from sources of ignition - No smoking.
Conditions for safe storage, including any incompatibilities: Keep container tightly closed. Keep away from sources of ignition - No smoking.
Storage Stability: Material is stable under normal conditions.

Transport information

Land transport (UN RTDG/ADR/RID)

UN number:
2927
Shipping information
Proper shipping name and description:
TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.(Gamma-Isocyanatopropyltrimethoxysilane)
Chemical name:
Gamma-Isocyanatopropyltrimethoxysilane
Language:
English
Class or division:
Class 6: Toxic and infectious substances; Division 6.1
Packing group:
Packing group II: Substances presenting medium danger
Labels:
6.1, 8
SpecialProvisionsopen allclose all

Inland waterway transport (UN RTDG/ADN(R))

UN number:
2927
Shipping information
Proper shipping name and description:
TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.(Gamma-Isocyanatopropyltrimethoxysilane)
Chemical name:
Gamma-Isocyanatopropyltrimethoxysilane
Subsidiary hazard(s):
Class 6: Toxic and infectious substances; Division 6.1
Labels:
6.1, 8
Remarksopen allclose all

Marine transport (UN RTDG/IMDG)

UN number:
2927
Shipping information
Proper shipping name and description:
TOXIC LIQUID, CORROSIVE, ORGANIC, N.O.S.(Gamma-Isocyanatopropyltrimethoxysilane)
Chemical name:
Gamma-Isocyanatopropyltrimethoxysilane
Class or division:
Class 6: Toxic and infectious substances; Division 6.1
Packing group:
Packing group II: Substances presenting medium danger
EmS code:
F-A
S-B
Labels:
6.1, 8
Remarksopen allclose all

Air transport (UN RTDG/ICAO/IATA)

UN number:
2927
Shipping information
Proper shipping name and description:
Toxic liquid, corrosive, organic, n.o.s.(Gamma-Isocyanatopropyltrimethoxysilane)
Chemical name:
Gamma-Isocyanatopropyltrimethoxysilane
Class or division:
Class 6: Toxic and infectious substances; Division 6.1
Packing group:
Packing group II: Substances presenting medium danger
Labels:
6.1, 8
Remarksopen allclose all
SpecialProvisionsopen allclose all

Exposure controls / personal protection

Exposure controls/Appropriate Engineering Controls:
Handle in closed system. Provide eyewash station and safety shower. Provide adequate ventilation, including appropriate local extraction, to ensure that the defined occupational exposure limit is not exceeded.

General information: Use only in well-ventilated areas. Do not eat, drink or smoke when using the product. Wash hands after handling. Practice good housekeeping.
Eye/face protection: Face shield
Skin protection/Hand Protection:
Advice: CE approved protective gloves, Material: 890 Vitoject, Minimum break through time: 480 min
Glove thickness: 0,7 mm. Guideline: EN 374
Other: Long sleeves Safety shoes
Respiratory Protection: Respirator with a vapour filter (EN 141)
Hygiene measures: Always observe good personal hygiene measures, such as washing after handling the material and before eating, drinking, and/or smoking. Routinely wash work clothing to remove contaminants. Discard contaminated footwear that cannot be cleaned. Wear suitable gloves and eye/face protection. Avoid inhalation of vapors and spray mists.
Environmental exposure controls: No release to wastewater from process as such, wastewater emissions limited to release generated from final equipment cleaning step using water

Stability and reactivity

Chemical Stability: Material is stable under normal conditions.
Possibility of hazardous reactions: Hazardous polymerization does not occur.
Conditions to avoid: Avoid contact with: Moisture.
Incompatible Materials: Alcohols. Oxidizing agents. Reacts with water or moisture to form: Methanol Reacts violently with strong alkaline substances.
Hazardous Decomposition Products: In case of fire, gives off (emits): Carbon oxides Oxides of silicon. Nitrogen Oxides Carbon monoxide is highly toxic if inhaled; carbon dioxide in sufficient concentrations can act as an asphyxiant. Acute overexposure to the products of combustion may result in irritation of the respiratory tract.

Disposal considerations

Waste treatment methods
General information: See Section Exposure controls/personal protection for information on appropriate personal protective equipment. The generation of waste should be avoided or minimized wherever possible. Do not discharge into drains, water courses or onto the ground.
Disposal methods: Can be incinerated when in compliance with local regulations.