Registration Dossier
Registration Dossier
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EC number: 268-083-8 | CAS number: 68002-70-0 This substance is identified by SDA Substance Name: C16-C22 trialkyl glyceride and SDA Reporting Number: 21-001-00.
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
Short description of key information:
No considered to be genotoxic.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
The weight of evidence from structurally similar substances of the same read-across category suggests that ‘glycerides, C16-22 (SDA Reporting Number: 21-001-00)’ is unlikely to exhibit genotoxic activity in bacterial reverse mutation (Ames) assays, in vitro mammalian chromosome aberration tests with Chinese hamster ovary cells and/or an in vivo mouse micronucleus or chromosomal aberration assay. Further, predictions from the Danish QSAR database and Toxtree (v.1.6) did not reveal any evidence for genotoxic activity in either in vitro bacterial or mammalian cell systems orin vivo test systems.
The above evidence, added to the very long history of safe use of these substances in nutritional (food and feed), cosmetic and industrial uses, suggests that ‘glycerides, C16-22 (SDA Reporting Number: 21-001-00)’ does not have a mutagenic potential.
Based on the above information, the substance does not qualify for mutagenicity classification according to Directive 67/548 EC or Regulation 1272/2008/EC.
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