Registration Dossier
Registration Dossier
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EC number: 200-814-8 | CAS number: 74-84-0
Carcinogenicity
Administrative data
Description of key information
No specific carcinogenicity data are available on the Petroleum Gases, however, their simple chemical structures with no reactive groups and no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that C1-C4 alkanes are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.
Key value for chemical safety assessment
Justification for classification or non-classification
Members of Petroleum Gases have a low potential for carcinogenicity and therefore do not warrant classification under GHS/CLP.
Additional information
There are no carcinogenicity studies available for any of the C1 - C4 alkane gases which comprise the Petroleum Gases category. However, weight of evidence from subchronic tests (up to 90 days), a consideration of their simple chemical structures, which have no reactive groups and carry no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis ( Tennant RW and Ashby J (1991). Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals by the US National Toxicology Program. Mutat Res 257 (3) 209-227), together with the conclusion that C1-C4 alkanes are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity. Taking these data into account, together with the general lack of toxicity across other endpoints, it is considered that there is no justification for conducting further animal carcinogenicity studies. The above reasoning leads to the conclusion that Petroleum Gases category can be considered to have low concern for human carcinogenicity.
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