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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Carcinogenicity

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Administrative data

Description of key information

No specific carcinogenicity data are available on the Petroleum Gases, however, their simple chemical structures with no reactive groups and no structural alerts for likely genotoxic carcinogenic activity, together with the conclusion that C1-C4 alkanes are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity.

Key value for chemical safety assessment

Justification for classification or non-classification

Members of Petroleum Gases have a low potential for carcinogenicity and therefore do not warrant classification under GHS/CLP.

Additional information

There are no carcinogenicity studies available for any of the C1 - C4 alkane gases which comprise the Petroleum Gases category. However, weight of evidence from subchronic tests (up to 90 days), a consideration of their simple chemical structures, which have no reactive groups and carry no alerts for likely genotoxic carcinogenic activity from established Structure Activity Relationship analysis ( Tennant RW and Ashby J (1991). Classification according to chemical structure, mutagenicity to Salmonella and level of carcinogenicity of a further 39 chemicals by the US National Toxicology Program.  Mutat Res 257 (3) 209-227), together with the conclusion that C1-C4 alkanes are not genotoxic, provide a strong case for concluding that none will show any significant carcinogenic activity. Taking these data into account, together with the general lack of toxicity across other endpoints, it is considered that there is no justification for conducting further animal carcinogenicity studies. The above reasoning leads to the conclusion that Petroleum Gases category can be considered to have low concern for human carcinogenicity.