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Adsorption / desorption

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Reference
Endpoint:
adsorption / desorption: screening
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2008
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study completed under GLP
Qualifier:
according to guideline
Guideline:
OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))
Deviations:
not specified
Qualifier:
according to guideline
Guideline:
EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))
Deviations:
not specified
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC estimation method
Media:
soil/sewage sludge
Test temperature:
35 +- 1°C
Details on study design: HPLC method:
Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA) Detector: Dual lambda Absorbance Detector 2487 (Waters) Column: 150 mm x 4.6 mm id. Hypersil BDS-CN; dp = 5 microm (Thermo, San Jose, CA, USA) Column temperature: 35 +- 1 °C Mobile phase neutral pH: 30/70 (v/v) methanol/water Flow: 1 ml/min Injection volume: 10 microL UV detection: 210 nm
Analytical monitoring:
yes
Type:
Koc
Value:
< 20.9 dimensionless
Temp.:
35 °C
Type:
log Koc
Value:
< 1.32 dimensionless
Temp.:
35 °C
Validity criteria fulfilled:
not specified
Conclusions:
log Koc of the test substance was < 1.32 (Koc < 20.9)
Executive summary:

The log Koc of MPKO was determined by means of HPLC. In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9)

Description of key information

Key value for chemical safety assessment

Koc at 20 °C:
20.9

Additional information

One study investigating the adsorption of 2-Pentanone oxime was available. The adsorption coefficient was determined in a GLP-study according to OECD guideline 121 using HPLC. The determined log Koc was < 1.32 (KOC: < 20.9).

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