N-pentan-2-ylidenehydroxylamine

Adsorption / desorption

Link to relevant study record(s)

Reference

Endpoint:

adsorption / desorption: screening

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2008

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Guideline study completed under GLP

Qualifier:

according to guideline

Guideline:

OECD Guideline 121 (Estimation of the Adsorption Coefficient (Koc) on Soil and on Sewage Sludge using High Performance Liquid Chromatography (HPLC))

Deviations:

not specified

Qualifier:

according to guideline

Guideline:

EU Method C.19 (Estimation of the Adsorption Coefficient (KOC) on Soil and Sewage Sludge Using High Performance Liquid Chromatography (HPLC))

Deviations:

not specified

GLP compliance:

yes (incl. QA statement)

Type of method:

HPLC estimation method

Media:

soil/sewage sludge

Test temperature:

35 +- 1°C

Details on study design: HPLC method:

Instrument: Alliance Separation Module 2695 (Waters, Milford, MA, USA) Detector: Dual lambda Absorbance Detector 2487 (Waters) Column: 150 mm x 4.6 mm id. Hypersil BDS-CN; dp = 5 microm (Thermo, San Jose, CA, USA) Column temperature: 35 +- 1 °C Mobile phase neutral pH: 30/70 (v/v) methanol/water Flow: 1 ml/min Injection volume: 10 microL UV detection: 210 nm

Analytical monitoring:

yes

Type:

Koc

Value:

< 20.9 dimensionless

Temp.:

35 °C

Type:

log Koc

Value:

< 1.32 dimensionless

Temp.:

35 °C

Validity criteria fulfilled:

not specified

Conclusions:

log Koc of the test substance was < 1.32 (Koc < 20.9)

Executive summary:

The log Koc of MPKO was determined by means of HPLC. In the chromatogram of the test solution, one test substance peak was observed at a retention time of 2.6 minutes. Under the same analytical conditions, the retention time of phenol (log Koc = 1.32) was 3.1 minutes. Hence, it was concluded that the log Koc of the test substance was < 1.32 (Koc < 20.9)

Key value for chemical safety assessment

Koc at 20 °C:

20.9

Additional information

One study investigating the adsorption of 2-Pentanone oxime was available. The adsorption coefficient was determined in a GLP-study according to OECD guideline 121 using HPLC. The determined log Koc was < 1.32 (KOC: < 20.9).