Phosphoryl trichloride

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

other: Direct observations, poisoning incidents

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Risk assessment, direct observations, poisoning incidents

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Phosphoroxidchlorid [MAK Value Documentation in German language, 1984]

Author:

MAK

Year:

1984

Bibliographic source:

Wiley-VCH Verlag, The MAK Collection for Occupational Health and Safety, 1-10.

Reference 2

Reference Type:

publication

Title:

Vergleichende Toxizität von Phosphor-Chlorverbindungen (POCl3, PCl3, PCl5) bei einmaliger und wiederholter Exposition [Comparative toxicity of the chloride compounds of phosphorus (POCl3, PCl3, PCl5) in single and repeated exposures]

Author:

Molodkina NN

Year:

1974

Bibliographic source:

Nov Prom Khim Veshch, 13, 107-114

Reference 3

Reference Type:

publication

Title:

Peculiarities of the biological action exerted by phosphorus oxychloride

Author:

Molodkina NN

Year:

1971

Bibliographic source:

Gigiena Truda i Professional'nye Zabolevaniia, 10, 30-34

Reference 4

Reference Type:

publication

Title:

Intoxication collective professionelle par l'oxychlorure de phosphore [Collective occupational intoxication by phosphorus oxychloride]

Author:

Oltramare M, Bahy M, Desbaumes P, Voinier B

Year:

1975

Bibliographic source:

Archives des Maladies Professionelles de Medecine du Travail et de Securite Sociale, 36, 438-440

Reference 5

Reference Type:

publication

Title:

Malattie causate da fosforo e composti [Illnesses caused by phosphorus and compounds]

Author:

Parmeggiani L

Year:

1953

Bibliographic source:

Medicina del Lavoro, 44, 263-265

Reference 6

Reference Type:

publication

Title:

Le syndrome de dysfonction reactive des voies aeriennes; une forme particulere d'asthma professionnel

Author:

Rivoire B, Carre P, Lasfragues G, Moline J, Lavandier M

Year:

1996

Bibliographic source:

Archives des Maladies Professionnelles et de Medicine de Travail, 57, 136

Reference 7

Reference Type:

publication

Title:

Poisoning caused by inhalation of hydrogen chloride, phosphorus oxychloride, phosphorus pentachloride, oxalic acid

Author:

Rosenthal T, Baum GL, Frand U, Molho M

Year:

1978

Bibliographic source:

Chest 73 (5), 623-626

Reference 8

Reference Type:

publication

Title:

Chloro compounds of phosphorus as industrial hazards.

Author:

Roshchin AV, Molodkina NN

Year:

1977

Bibliographic source:

Journal of Hygiene, Epidemiology, Microbiology and Immunology, 21(4), 387-394.

Reference 9

Reference Type:

publication

Title:

Contributo clinico alla conoscenza dell' intossicazione acuta da ossicloruro di fosforo

Author:

Scotti P

Year:

1967

Bibliographic source:

Minerva Medica, 58, 129-131

Reference 10

Reference Type:

publication

Title:

Recent occupational diseases in Japan

Author:

Tati M

Year:

1988

Bibliographic source:

Asian medical journal 31, 301-307

Materials and methods

Type of study / information:

Risk assessment, direct observations, poisoning incidents in humans

Endpoint addressed:

respiratory irritation

Principles of method if other than guideline:

Risk assessment, direct observations, poisoning incidents

Test material

Test material information

Constituent 1

Reference substance name:

Phosphoryl trichloride

EC Number:

233-046-7

EC Name:

Phosphoryl trichloride

Cas Number:

10025-87-3

Molecular formula:

Cl3OP

IUPAC Name:

phosphoroyl trichloride

Method

Details on study design:

Risk assessment, direct observations, poisoning incidents in humans

Results and discussion

Results:

Phosphoryl trichloride is a severely corrosive, colorless liquid of pungent odor. In contact with water, humid air or water containing liquids phosphoryl trichloride reacts to produce heat, phosphoric acid, and hydrochloric acid. A marked irritation to mucous membranes of eyes and respiratory tract is the most pronounced effect.
The moderate solubility in water may cause a delay of the start of reaction and enable phosphoryl trichloride to reach the deeper parts of the respiratory tract.
Additionally irritation is only weak at the beginning and sign of intoxication develop within several hours. These properties produce little warning at the start of exposure and severe, long-lasting effects can arise.
Symptoms after acute exposure are: reddening of mucous membranes, inflammation of eyes, lacrimation, dry cough, dyspnea, corrosion of airways, lung edema. Additionally headache, nausea, fatigue, vomiting were reported. Long term effects: obstructive lung disease, increased sensitivity to irritants and infection.
Long term, low level exposure can produce liver and kidney changes, changes in bone structure and mutagenic effects in animals.
Direct skin contact causes all stages of irritation and corrosion depending on duration and the presence of water at the site of exposure. Similar effects occur in the digestive tract after ingestion.