Phosphoryl trichloride

Repeated dose toxicity: inhalation

Administrative data

Endpoint:

sub-chronic toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

data from handbook or collection of data

Data source

Reference

Reference Type:

secondary source

Title:

OECD SIDS for phosphoryl trichloride CAS No. 10025-87-3

Author:

OECD SIDS

Year:

2006

Bibliographic source:

Organisation for Economic Co-Operation and Development (OECD), Screening Information Data Set (SIDS) for Phosphoryl Trichloride CAS No. 10025-87-3, UNEP publication

Report date:

2006

Materials and methods

Principles of method if other than guideline:

In a 90-day inhalation study using B6C3F1 mice, Sprague-Dawley, and Fisher 344 rats groups of 31 males and 31 females of each species and strain were exposed (whole body) to HCl at 0, 10, 20 or 50 ppm (0, 15, 30, or 75 mg/m3), 6 h/day, 5 days/week for 90 days.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

Hydrogen chloride

EC Number:

231-595-7

EC Name:

Hydrogen chloride

Cas Number:

7647-01-0

Molecular formula:

ClH

IUPAC Name:

hydrogen chloride

Test material form:

gas

Details on test material:

gaseous hydrogen chloride

Test animals

Species:

other: rat and mouse

Strain:

other: Sprague Dawley, fisher 344 rats, and B6C3F1 mice

Sex:

male/female

Administration / exposure

Route of administration:

inhalation: gas

Type of inhalation exposure:

whole body

Vehicle:

air

Remarks on MMAD:

MMAD / GSD: not applicable

Analytical verification of doses or concentrations:

not specified

Duration of treatment / exposure:

6 h/day, 5 days/week for 90 days

Frequency of treatment:

daily

Doses / concentrations

Remarks:

Doses / Concentrations:
0, 10, 20, or 50 ppm (0, 15, 30 or 75 mg/m³)
Basis:
nominal conc.

No. of animals per sex per dose:

31 males and 31 females of each species and strain/dose

Control animals:

yes, concurrent vehicle

Results and discussion

Effect levels

Dose descriptor:

LOAEC

Remarks:

local

Effect level:

15 mg/m³ air

Based on:

test mat.

Sex:

male/female

Basis for effect level:

other: Severe irritation/corrosion effect at the site of entry.

Target system / organ toxicity

Critical effects observed:

not specified

Any other information on results incl. tables

Several animals died during the study; however, the deaths did not appear to be exposure related. There was a slight, but significant

decrease in body weight gain in male and female mice and male Fisher 344 rats in the high dose groups. There was no effect on hematology, clinical chemistry, and urinalysis. Histologic examination showed minimum to mild rhinitis in both strains of rats. Lesions occurred in the anterior portion of the nasal cavity and were concentration and time related. In mice exposed to 50 ppm, there was cheilitis and accumulation of macrophages in the peripheral tissues after 90 days. Mice in all exposure groups developed eosinophilic globules in the epithelial lining of the nasal tissues

Applicant's summary and conclusion

Conclusions:

All findings were confined to the site of first contact and can be explained by the irritating/corrosive properties of the acid. No signs of systemic effects were reported. Therefore systemic availability is unlikely. The local NOAEC is below 10 ppm (15 mg/m³). No statement is possible about a systemic NOAEC because of the severe irritation/corrosion effect occurring at the site of entry. Potential systemic effects are considered as consequences of these local effects.

Executive summary:

In a 90-day inhalation study using B6C3F1 mice, Sprague-Dawley, and Fisher 344 rats groups of 31 males and 31 females of each species and strain were exposed (whole body) to HCl at 0, 10, 20 or 50 ppm (0, 15, 30, or 75 mg/m³), 6 h/day, 5 days/week for 90 days. Several animals died during the study; however, the deaths did not appear to be exposure related. There was a slight, but significant decrease in body weight gain in male and female mice and male Fisher 344 rats in the high dose groups. There was no effect on hematology, clinical chemistry, and urinalysis. Histologic examination showed minimum to mild rhinitis in both strains of rats. Lesions occurred in the anterior portion of the nasal cavity and were concentration and time related. In mice exposed to 50 ppm, there was cheilitis and accumulation of macrophages in the peripheral tissues after 90 days. Mice in all exposure groups developed eosinophilic globules in the epithelial lining of the nasal tissues.

 

All findings were confined to the site of first contact and can be explained by the irritating/corrosive properties of the acid. No signs of systemic effects were reported. Therefore systemic availability is unlikely. The local NOAEC is below 10 ppm (15 mg/m³). No statement is possible about a systemic NOAEC because of the severe irritation/corrosion effect occurring at the site of entry. Potential systemic effects are considered as consequences of these local effects.