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Diss Factsheets

Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
other information
Justification for type of information:
Data from structural related substance (see attached justification)
Cross-reference
Reason / purpose for cross-reference:
read-across source
Reference
Endpoint:
toxicity to reproduction: other studies
Type of information:
other: Histopathological examination of all major organs in a 90 day inhalation study with hydrogen chloride
Adequacy of study:
other information
Reliability:
other: Histopathological examination of all major organs in a 90 day inhalation study with hydrogen chloride
Species:
rat
Sex:
male/female
Dose descriptor:
NOAEL
Effect level:
20 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: see Remarks
Daily exposure of rats to gaseous hydrogen chloride at concentrations of 10, 20 and 50 ppm, 6 hours a day, 5 days per week up to a 90 day exposure period affected the body weight of males of one of the strains of rats at the highest dose level. Clinical signs observed were mainly related to the irritant/corrosive properties of hydrogen chloride: crusty nose, red or yellow/brown stained fur, poor quality coat, crusty eye(s) and nasal discharge in rats. No exposure-related changes were seen in haematology or clinical chemistry parameters or urinalysis, and no peculiar gross observations were noted at necropsy. Decreased liver weights and increases in other organs were recorded, but these changes were considered to be mainly related to the effect of treatment on general growth of the affected animals rather than direct effects on the organs themselves.
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.

Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.
Conclusions:
Daily exposure of rats to gaseous hydrogen chloride at concentrations of 10, 20 and 50 ppm, 6 hours a day, 5 days per week up to a 90 day exposure period affected the body weight of males of one of the strains of rats at the highest dose level. Clinical signs observed were mainly related to the irritant/corrosive properties of hydrogen chloride: crusty nose, red or yellow/brown stained fur, poor quality coat, crusty eye(s) and nasal discharge in rats. No exposure-related changes were seen in haematology or clinical chemistry parameters or urinalysis, and no peculiar gross observations were noted at necropsy. Decreased liver weights and increases in other organs were recorded, but these changes were considered to be mainly related to the effect of treatment on general growth of the affected animals rather than direct effects on the organs themselves.
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.

Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.

Data source

Materials and methods

Test material

Constituent 1
Chemical structure
Reference substance name:
Phosphoryl trichloride
EC Number:
233-046-7
EC Name:
Phosphoryl trichloride
Cas Number:
10025-87-3
Molecular formula:
Cl3OP
IUPAC Name:
phosphoroyl trichloride

Test animals

Species:
rat
Sex:
male/female

Results and discussion

Effect levels

Dose descriptor:
NOAEL
Effect level:
20 ppm
Based on:
test mat.
Sex:
male/female
Basis for effect level:
other: see Remarks

Observed effects

Daily exposure of rats to gaseous hydrogen chloride at concentrations of 10, 20 and 50 ppm, 6 hours a day, 5 days per week up to a 90 day exposure period affected the body weight of males of one of the strains of rats at the highest dose level. Clinical signs observed were mainly related to the irritant/corrosive properties of hydrogen chloride: crusty nose, red or yellow/brown stained fur, poor quality coat, crusty eye(s) and nasal discharge in rats. No exposure-related changes were seen in haematology or clinical chemistry parameters or urinalysis, and no peculiar gross observations were noted at necropsy. Decreased liver weights and increases in other organs were recorded, but these changes were considered to be mainly related to the effect of treatment on general growth of the affected animals rather than direct effects on the organs themselves.
Histopathological examination after 90 days exposure revealed minimal to mild rhinitis in both strains of rats.

Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.

Applicant's summary and conclusion

Conclusions:
Based on effects on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.
Based on the lack of effects on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.

Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid (t1/2 < 10 seconds) (Hansel, 2004). Toxicological effects are expected mostly from exposure to these degradation products.
Therefore, a read-across with the degradation products is justified (see attached justification: Justification for a read-across of Phosphoryl trichloride (CAS no. 10025-87-3, EC no. 233-046-7) [Target] and its hydrolysis products phosphoric acid (CAS no. 7664-38-2, EC no. 231-633-2) [Source] and hydrochloric acid (CAS no. 7647-01-0, EC no. 231-595-7) [Source] concerning toxicity and ecotoxicity).
Executive summary:

Phosphoryl trichloride hydrolyzes in water within seconds, forming phosphoric acid and hydrochloric acid (t1/2 < 10 seconds) (Hansel, 2004). Toxicological effects are expected mostly from exposure to these degradation products.

Therefore, a read-across with the degradation products is justified (see attached justification: Justification for a read-across of Phosphoryl trichloride (CAS no. 10025-87-3, EC no. 233-046-7) [Target] and its hydrolysis products phosphoric acid (CAS no. 7664-38-2, EC no. 231-633-2) [Source] and hydrochloric acid (CAS no. 7647-01-0, EC no. 231-595-7) [Source] concerning toxicity and ecotoxicity).

 

Based on effects of hydrogen chloride on body weight both strains of rats, the LOAEL is considered to be 50 ppm in rats.

Based on the lack of effects of hydrogen chloride on body weight and the lack of pathological findings except for effects of site-of-contact local irritation, the NOAEL for repeated dose inhalation toxicity can be set at 20 ppm for rats. The NOEL, at least for rats, can be set at 10 ppm.