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EC number: 231-177-4 | CAS number: 7440-69-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Toxicological Summary
- Administrative data
- Workers - Hazard via inhalation route
- Workers - Hazard via dermal route
- Workers - Hazard for the eyes
- Additional information - workers
- General Population - Hazard via inhalation route
- General Population - Hazard via dermal route
- General Population - Hazard via oral route
- General Population - Hazard for the eyes
- Additional information - General Population
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13.1 mg/m³
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Additional information - workers
There is one repeated dose oral toxicity study available aimed to characterise the potential toxic effects of bismuth metal following oral administration for 28 days at dose levels of 0, 40, 200 and 1000 mg/kg bw daily in male and female Sprague-Dawley rats with a recovery period of 14 days.The results did not indicate any changes attributed to treatment with bismuth metal in either males or females in the dose groups up to 1000 mg/kg. Thus, a NOAEL of 1000 mg/kg bw/d was established for bismuth metal based on the lack of toxicologically relevant effects at the highest dose tested and was selected as starting point for DNEL derivation.
Modification of the dose descriptor is necessary, because the routes of exposure are different between animals (oral) and humans (inhalation). For this purpose the default respiratory volume for the rat corresponding to the daily duration of human exposure is considered in the first step, followed by a correction for the difference between respiratory rates of workers under standard conditions and under light activity in the second step.
The following corrected NAECinhalation(no adverse effects concentrations) is calculated for humans (for details on the calculation refer to the report “Derivation of DENLs for bismuth metal and dibismuth trioxide” attached to the dossier):
Bismuth metal: 1763 mg/m3
In principle, further correction for differences in the rates of absorption for the oral and the inhalation routes in rats and humans can be considered. However, because oral absorption is very low in rats and can per default be assumed at about 0.5 %, and absorption in human following the inhalation route is calculated to be in a similar range (0.5 and 0.6 %, respectively) for bismuth metal and dibismuth trioxide (see EBRC report 2010, Derivation of oral, dermal and inhalation absorption factors for bismuth metal and bismuth compounds; IUCLID section 7.1), no further correction is considered.
For more details refer to the report "Derivation of DNELs for bismuth metal and dibismuth trioxide" attached to technical dossier.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13.3 mg/kg bw/day
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Additional information - General Population
There is one repeated dose oral toxicity study available aimed to characterise the potential toxic effects of bismuth metal following oral administration for 28 days at dose levels of 0, 40, 200 and 1000 mg/kg bw daily in male and female Sprague-Dawley rats with a recovery period of 14 days.The results did not indicate any changes attributed to treatment with bismuth metal in either males or females in the dose groups up to 1000 mg/kg. Thus, a NOAEL of 1000 mg/kg bw/d was established for bismuth metal based on the lack of toxicologically relevant effects at the highest dose tested and was selected as starting point for DNEL derivation.
Further modification of the dose descriptors is not necessary, because the routes of exposure are similar in animals (oral) and humans (oral).
For more details refer to the report "Derivation of DNELs for bismuth metal and dibismuth trioxide" attached to technical dossier.
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