Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 931-274-8
CAS number: 28182-81-2
Patient No 1: not relevant with regard to HDI oligomers, isocyanurate
Patient No 2: On patch testing, she reacted positively to one of the
three hardeners (Hardener B). Hardener B was composed of 68.5 %
aliphatic polyisocyanate (Desmodur N 3390 BA; Bayer AG), 12 % xylene,
and 19.5 % propylene glycol methyl ether acetate. In the second patch
test session, the patient was tested with the three ingredients of
Hardener B, and reacted positively to Desmodur N 3390 BA. The main
component in Desmodur N 3390 BA is an isocyanurate-type HDI trimer (90
%), and it also contained 10 % n-butylacetate. The patient was also
positive with another isocyanurate-type product, Desmodur® N 3300, and
with the biuret-type HDI trimer of patient no. 1, Desmodur N 3200. Nine
control patients were negative with 2 % Desmodur N 3200, and with 2 %
and 1 % Hardener B, all in pet.The patient had developed occupational
allergic contact dermatitis in response to isocyanurate-type HDI trimer
in Hardener B.
Patient No 3: On patch testing, he was positive with Desmodur N 3300 in
the isocyanate series. In the second patch test session, the Desmodur N
3300 reactions were reproduced, and he also reacted to three different
hardeners (Hardeners C, D, and E) from his work place, composed of
polymeric HDI. He avoided the grinding work, and the symptoms did not
reappear, but later he left the job. His diagnosis was occupational
contact allergy to aliphatic polyisocyanate (HDI homopolymer) rather
than allergic contact dermatitis, as it was not proven that the skin
symptoms were caused by the contact allergy. He might have been
sensitized earlier in the painting work, even though he had no symptoms
Patient No 4: On the first patch test session, she reacted to Desmodur N
3300 in the isocyanate series and was negative with monomeric HDI. She
had prepared pilot batches of two-component paints, the hardeners of
which contained HDI homopolymers. In the second patch test session, she
reacted to two hardeners from her workplace, Desmodur N 3900 and a
corresponding Japanese product (Hardener F). She also reacted to
Desmodur N 3200 (the biuret-type HDI trimer of patient no. 1) and again
to an isocyanurate-type HDI trimer, Desmodur N 3300. The latter gave
positive reactions down to 0.005%. The cause of this case, Desmodur N
3900, was mainly composed of asymmetric HDI trimer. Twenty control
patients were negative with Desmodur N 3900 (5%, 1.65% and 0.5% in
pet.). The patient was diagnosed with occupational allergic contact
dermatitis resulting from asymmetric HDI trimer in paint hardeners.
Cited from publication: "We describe 4 patients sensitized to products
based on HDI homopolymers. The allergic reactions cannot be explained by
sensitisation to HDI monomer, as none of the 4 patients reacted to HDI
monomer. Furthermore, the concentration of the monomer in the products
is very low."
"When patch-tested, all of the patients reacted not only to the specific
type of trimer to which they were exposed, but also to other types of
HDI trimer. Owing to structural similarity, there can be cross-allergy
between the different types of trimer."
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Do not show this message again