Registration Dossier
Registration Dossier
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EC number: 931-274-8 | CAS number: 28182-81-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Effect on fertility: via oral route
- Endpoint conclusion:
- no study available
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A data waiving is claimed for toxicity to reproduction for HDI oligomers, isocyanurate type. A full and detailed text elaborating the data waiving is attached to this endpoint summary.
Justification for selection of Effect on fertility via inhalation route:
No definite reproductive toxicity study is available for the substance. Based on read-across two reproductive toxicity screenings are available, but none is selected here, since both are considered relevant for assessment.
Effects on developmental toxicity
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no adverse effect observed
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Additional information
A data waiving is claimed for developmental toxicity for HDI oligomers, isocyanurate type. A full and detailed text elaborating the data waiving is attached to this endpoint summary.
Justification for selection of Effect on developmental toxicity: via oral route:
Inhalation is the relevant route of exposure during use.
Justification for selection of Effect on developmental toxicity: via inhalation route:
No study is selected, since three fully reliable developmental toxicity studies are available based on read across, and are all considered relevant for assessment.
Justification for selection of Effect on developmental toxicity: via dermal route:
Inhalation is the relevant route of exposure during use.
Justification for classification or non-classification
According to Regulation (EC) No 1272/2008, Annex I, no classification is warranted for toxicity to reproduction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
