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EC number: 204-697-4 | CAS number: 124-40-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- Method: other: BASF-Test: Four animals were treated for 3 min and two animals were treated for 4 hour using occlusive conditions. An application site of 2 x 2 cm was covered with the liquid test substance. After the application the skin was washed with Lutrol (50 %). The report describes findings after 24 hours and at the end of the observation period (8 days).
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethylamine
- EC Number:
- 204-697-4
- EC Name:
- Dimethylamine
- Cas Number:
- 124-40-3
- Molecular formula:
- C2H7N
- IUPAC Name:
- N-methylmethanamine
- Details on test material:
- Dimethylamin, 40%-ige waessrige Loesung
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
Test system
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not specified
- Duration of treatment / exposure:
- 3 min and 4 h
- Observation period:
- 8 days
- Number of animals:
- 3 min exposure: 2
4 h exposure: 4 - Details on study design:
- TEST SITE
- Area of exposure: 2 x 2 cm
REMOVAL OF TEST SUBSTANCE
- Washing (if done): Lutrol and Lutrol/water (1:1)
- Time after start of exposure: 3 min and 4 h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time: 3 min
- Basis:
- animal #1
- Remarks:
- Animal No. 1 of a total of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 2 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time: 3 min
- Basis:
- animal #2
- Remarks:
- Animal No. 2 of a total of 2
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 2 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time: 3 min
- Basis:
- animal #1
- Remarks:
- Animal No. 1 or a total of 2
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- The score given above is the mean value reported for the 2 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 3 min
- Basis:
- animal #2
- Remarks:
- Animal No. 2 of a total of 2
- Time point:
- 24 h
- Score:
- 0.5
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 2 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4h
- Basis:
- animal #1
- Remarks:
- Animal No. 1 of a total of 4
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #2
- Remarks:
- Animal No. 2 of a total of 4 animals
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #3
- Remarks:
- Animal No. 3 of a total of 4
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #4
- Remarks:
- Animal No. 4 of a total of 4
- Time point:
- 24 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #1
- Remarks:
- Animal No. 1 of a total of 4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #2
- Remarks:
- Animal No. 2 of a total of 4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #3
- Remarks:
- Animal No. 3 of a total of 4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #4
- Remarks:
- ANimal No. 4 of a total of 4
- Time point:
- 24 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- Observation period 8 days
- Remarks on result:
- probability of severe irritation
- Remarks:
- The score given above is the mean value reported for the 4 animals
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 3 min and Exposure time 4 h
- Basis:
- animal #1
- Time point:
- 48 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 3 min and Exposure time 4 h
- Basis:
- animal #2
- Time point:
- 48 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 3 min and Exposure time 4 h
- Basis:
- animal #1
- Time point:
- 72 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 3 min and Exposure time 4 h
- Basis:
- animal #2
- Time point:
- 72 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #3
- Time point:
- 48 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- erythema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #4
- Time point:
- 48 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #3
- Time point:
- 72 h
- Reversibility:
- other: As no value has been reported:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- edema score
- Remarks:
- Exposure time 4 h
- Basis:
- animal #4
- Time point:
- 72 h
- Reversibility:
- other: As no value has been repoted:
- Remarks:
- not applicable
- Remarks on result:
- other: The time points reported were 24 hours and 8 days
- Remarks:
- not stated
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Remarks on result:
- not measured/tested
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Classification: corrosive (causes burns)
- Executive summary:
A BASF AG internal procedure for skin irritation was used as in following described: two animals were treated with a 40 % DMA solution for 3 min and 4 animals for 4 hours using occlusive conditions. An application site of 2 x 2 cm was covered with the liquid test substance. After the application the skin was washed with Lutrol (50%). The animals were observed for 8 days and skin changes were recorded daily. On days 1 to 8 the exposure sites were examined and scored for erythema and edema on a graded scale of 0 to 2 or 4 respectively. The test substance was corrosive to the skin of rabbits. The report describes findings after 24 hours and at the end of the observation period (8 days). The 3 min exposure caused in every animal severe erythema and slight edema. The 4 h exposure caused severe erythema and severe edema.
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