Registration Dossier
Registration Dossier
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EC number: 209-942-9 | CAS number: 598-62-9
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
3 hour EC50 > 1000 mg/L; 3 hour NOEC = 1000 mg/L, OECD 209, EU Method C.11, EPA OPPTS 850.6800, Youngs (2010) MnO
Key value for chemical safety assessment
- EC10 or NOEC for microorganisms:
- 1 000 mg/L
Additional information
A study was performed to assess the effect of the test substance on the respiration of activated sewage sludge. The method followed that described in the OECD Guidelines for Testing of Chemicals (1984) No 209 "Activated Sludge, Respiration Inhibition Test", Method C.11 of Commission Regulation (EC) No. 440/2008 and US EPA Draft Ecological Effects Test Guidelines OPPTS 850.6800.
During the study activated sewage sludge was exposed to an aqueous dispersion of the test substance at concentrations of 10, 32, 100, 320 and 1000 mg/L for a period of 3 hours at a temperature of approximately 21°C with the addition of a synthetic sewage as a respiratory substrate. The rate of respiration was determined after 3 hours contact time and compared to data for the control and a reference item, 3,5-dichlorophenol.
The effect of the test substance on the respiration of activated sewage sludge gave a 3 hour EC50 of greater than 1000 mg/L. The No Observed Effect Concentration (NOEC) after 3 hours exposure was1000 mg/L.
It was considered unnecessary and unrealistic to test at concentrations in excess of 1000 mg/L.
Since the study was conducted with manganese oxide, rather than with the registered substance itself, it was assigned a relibality score of 2 according to the criteria of Klimisch (1997). Use of data on MnO to address data requirements of MnCO3 is considered to be justified on the basis that analogous results were obtained following chronic daphnia, and algae, testing with both substances, both substances display similar TDp results suggesting similar levels of metal release in environmentally relevant waters, and manganese is in the same oxidation state in both substance; furthermore, the anions are not expected to cause aquatic toxicity.
Overall, findings from the study on microorganisms, conducted with MnO, indicating there are no toxic effects elicited by Mn at the limit of solubility, support the conclusion that the substance is not hazardous to the aquatic environment.
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