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Toxicity to other above-ground organisms

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toxicity to other above-ground organisms
Type of information:
experimental study
Adequacy of study:
key study
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
no guideline followed
Principles of method if other than guideline:
Dietary toxicity study in dogs
GLP compliance:
not specified
Test organisms (species):
other: Canis familiaris
Details on test organisms:
female beagle dogs, 7 to 8 months old
Study type:
laboratory study
Total exposure duration:
183 d
Nominal and measured concentrations:
0.58, 1.15, 2.31 mg As/ kg diet
Key result
183 d
Dose descriptor:
other: NOEL
Effect conc.:
1.04 other: mg/kg bw/d
Nominal / measured:
not specified
Conc. based on:
Basis for effect:
other: growth, feed consumption
This study shows that dietary sodium arsenite causes a dose-dependent decrease of feed consumption and body weight in female dogs. A NOAEL of 1.04 mg As/kg bw/d was observed (based on a test concentration of 1.15 mg As/kg diet). Applying a conversion factorr of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Description of key information

The lowest NOAEL for mammals (1.04 mg As/kg diet) was observed in a 183-days study with female beagle dogs exposed to exposed to arsenic via food (Neiger and Osweiler, 1989). Applying a conversion factor of 40 (g bw/g diet per day), this NOAEL corresponds to a NOEC of 41.6 mg As/kg diet.

Key value for chemical safety assessment

Long-term EC10, LC10 or NOEC for mammals:
41.6 mg/kg food

Additional information