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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

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Description of key information

The bioactivity of Alcohols C12-13, branched and linear, ethoxylated (1-2,5 EO) sulphated, sodium salts (SPES) was assessed in a battery of in vitro tests relevant to systemic, reproductive, and developmental toxicity. Concentration-response curves were derived for 36 cell stress markers measured in HepG2 Cells and High Throughput Transcriptomics was conducted in HepG2, HepaRG and MCF7 cells. In vitro pharmacological profiling (IPP) of SPES against 73 targets was conducted, with specific follow-up with CALUX functional assays where necessary. Specific assays relating to developmental toxicity (Reprotracker, devTOXqp) were also conducted. Lowest reported Points of Departure (PoDs) were adjusted to correct for the activity of SPES (69.42%), and ranged from 1.1 - 89.8 µM. 


This data was used in a Next Generation Safety Assessment (NGSA), which is an exposure-led approach to safety assessment that employs the use of these New Approach Methodologies (NAMs). A full description of this approach can be found in Section 13.2 (Narrative Document/Next Generation Safety Assessment).

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