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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Exposure related observations in humans: other data

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Administrative data

Endpoint:
exposure-related observations in humans: other data
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Published data

Data source

Reference
Reference Type:
publication
Title:
Unnamed
Year:
1986

Materials and methods

Type of study / information:
human: Workplace exposure
Endpoint addressed:
not applicable
Test guideline
Qualifier:
according to guideline
Guideline:
other: not known
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Isobutyl methacrylate
EC Number:
202-613-0
EC Name:
Isobutyl methacrylate
Cas Number:
97-86-9
Molecular formula:
C8H14O2
IUPAC Name:
isobutyl methacrylate

Method

Details on study design:
Eight finger nail shops were monitored for ethyl, methyl and isobutyl methacrylate vapors. Passive  dosimeters or 
activated charcoaltubes were used. Sampling times ranged  from 17.4 to 40.4 minutes for intermittent samples and 
continuous  monitoring was conducted for 8-hr periods.

Results and discussion

Any other information on results incl. tables

Ethyl methacrylate
   Mean intermittent exposure (15 measurements): 
        13.4 ppm (63.6 mg/m3);  median = 9.8 ppm
   Mean continuous exposure (8h-TWA, 32 measurements): 
         7.3 ppm (34.7 mg/m3);  Median =  3.1 ppm

Methyl methacrylate
   Mean intermittent exposure (25 measurements): 
        20.3 ppm (83.0 mg/m3);  median = 18.5 ppm
   Mean continuous exposure (8h-TWA, 59 measurements): 
        5.3 ppm (21.7mg/m3);  Median = 4.0 ppm

Isobutyl methacrylate
   Mean intermittent exposure (5 measurements): 
        6.2 ppm (25.3 mg/m3);  median = 5.0 ppm
   Mean continuous exposure (8h-TWA, 5 measurements): 
        1.6 ppm (6.5 mg/m3);  Median = 1.3 ppm

Applicant's summary and conclusion

Conclusions:
In a reliable published study, isobutyl methacrylate   mean intermittent exposures were 25.3 mg/m3;  mean continuous exposure (8h-TWA)were 6.5 mg/m3.
Executive summary:

In a reliable published study, isobutyl methacrylate   mean intermittent exposures were 25.3 mg/m3;  mean continuous exposure (8h-TWA)were 6.5 mg/m3.