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EC number: 202-613-0 | CAS number: 97-86-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Federal Hazardous Substances Labeling Act Regulations, Section 191.12, Federal Register: 29, 13009 (1964)
- GLP compliance:
- no
Test material
- Reference substance name:
- Isobutyl methacrylate
- EC Number:
- 202-613-0
- EC Name:
- Isobutyl methacrylate
- Cas Number:
- 97-86-9
- Molecular formula:
- C8H14O2
- IUPAC Name:
- isobutyl methacrylate
Constituent 1
- Specific details on test material used for the study:
- Isobutyl methacrylate. Purity (99%) validated with documentation from Atofina (December, 2001).
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- New Zealand White Rabbits, female, weighing 2-2.5 kg.
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Each animal served as its own control: the untreated eye was used to provide control information.
- Amount / concentration applied:
- undiluted
Amount applied: 0.1 ml - Duration of treatment / exposure:
- 72 hour(s)
- Observation period (in vivo):
- 24, 48, 72 h
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Six NZ White rabbits were administered 0.1 ml (vol) of test compound into the everted lower lid of one eye of
each rabbit; eyelids were closed and held shut for 1 second. Prior to administration the eyes of each rabbit
were examined. Eyes remained unwashed. Eyes scored at 24, 48 and 72 hrs after administration with the aid
of an ophthalmoscope and Fluorescin sodium.
Comment: not rinsed
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal: #1, #2, #3, #4, #5, #6,
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- iris score
- Basis:
- animal: #1, #2, #3, #4, #5, #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal: #2, #5
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- not reversible
- Remarks:
- within 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 3
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- redness
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 3
- Reversibility:
- fully reversible
- Remarks:
- within 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- chemosis
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks:
- whithin 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- chemosis
- Basis:
- animal: #2, #3#, #4
- Time point:
- 24/48/72 h
- Score:
- 0.66
- Max. score:
- 4
- Reversibility:
- fully reversible within: 72 h
- Irritation parameter:
- conjunctivae score
- Remarks:
- chemosis
- Basis:
- animal: #5, #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- MEASURED ENDPOINT/INDEX (i.e. LD50, PII): PII = 1.67; scores were 2.17 (24 hr), 1.83 (48 hrs), and 1.0 (72 hrs).
RESULTS/OBSERVATIONS: Conjunctival irritation, redness (max. grade 2 in 3/6 rabbits) and chemosis (max. grade 2
in 1/6 rabbits) at 24 hr. Irritation (redness and chemosis), grade 2, was still present at 48 hr in 4/6 rabbits. At 72 hrs
the irritation (redness) was grade 2 in 1/6, grade 1 in 3/6; chemosis was grade 1 in 1/6 and 0 in 5/6 rabbits. There
was no involvement of the cornea or the iris.
Any other information on results incl. tables
Animal No. |
Corneal opacity/ Hornhauttrübung [Scores]
|
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
0 |
0 |
0 |
0 |
|
|
|
2 |
0 |
0 |
0 |
0 |
|
|
|
3 |
0 |
0 |
0 |
0 |
|
|
|
4 |
0 |
0 |
0 |
0 |
|
|
|
5 |
0 |
0 |
0 |
0 |
|
|
|
6 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
none |
|
|
|
|
|
|
|
|
Animal No. |
Iritis/ Regenbogenhautentzündung [Scores]
|
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
0 |
0 |
0 |
0 |
|
|
|
2 |
0 |
0 |
0 |
0 |
|
|
|
3 |
0 |
0 |
0 |
0 |
|
|
|
4 |
0 |
0 |
0 |
0 |
|
|
|
5 |
0 |
0 |
0 |
0 |
|
|
|
6 |
0 |
0 |
0 |
0 |
|
|
|
|
|
|
|
|
|
|
none |
|
|
|
|
|
|
|
|
Animal No. |
Conjunctiva redness (erythem) /Bindehautrötung [Scores]
|
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
2 |
2 |
2 |
2.0 |
|
|
|
2 |
2 |
1 |
1 |
1.3 |
|
|
|
3 |
1 |
1 |
1 |
1.0 |
|
|
|
4 |
1 |
1 |
0 |
0.7 |
|
|
|
5 |
2 |
1 |
1 |
1.3 |
|
|
|
6 |
0 |
1 |
0 |
0.3 |
|
|
|
|
|
|
|
1.1 |
|
|
none |
Animal No. |
Conjunctiva chemosis / Bindehautödem [Scores]
|
Mean Draize score |
Reversibility [scores] |
Hazard category |
|||
after 24 h |
after 48 h |
after 72 h |
in 7 days |
in 21 days |
|
||
1 |
2 |
1 |
1 |
1.3 |
|
|
|
2 |
1 |
1 |
0 |
0.7 |
|
|
|
3 |
1 |
1 |
0 |
0.7 |
|
|
|
4 |
1 |
1 |
0 |
0.7 |
|
|
|
5 |
0 |
0 |
0 |
0.0 |
|
|
|
6 |
0 |
0 |
0 |
0.0 |
|
|
|
|
|
|
|
0.6 |
|
|
none |
Classification: Hazard Category |
none |
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: REGULATION (EC) No 1272/2008 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 16 December 2008
- Conclusions:
- Classification: not irritating
- Executive summary:
In an occular irritation test acc. the federal Hazardous Substances and Labelling Act Regulations, Section 191.12 published in the Federal Register - 29 F.R. 13009, 1964. iso-butyl methacrylate (0.1 ml) was placed in the conjunctival sac of the right eye of six New Zealand White rabbits. The lids were then gently held together for one second. The test eyes were not washed out following the instillation. The left eye remained untreated for control. The eyes were examined at 1, 24, 48 and 72 hours. Eye irritation was scored for signs of corneal damage (density, area), iris reaction and lesions of the conjunctivae (erythema, chemosis, discharge). Additionally, the cornea was examined with the aid of fluorescein after recording the observations at 24 hours. No observation after 72 hrs. No animal showed corneal damage or iritis (mean scores: 0). The highest conjunctiva score for redness was 1.33 in 2/6 animals and the highest conjunctiva score for chemosis was 1.33 in 1/6 animals. In summary iso-butyl methacrylate is considered as slightly irritating to eyes.
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