Registration Dossier
Registration Dossier
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EC number: 205-011-6 | CAS number: 131-11-3
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Review of Soviet literature, primary source not available, only very short summary, no details on effects, no control data available
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Toxicology of Esters of o-Phthalic Acid and their Rating
- Author:
- Timofievskaya LA et al.
- Year:
- 1 980
- Bibliographic source:
- Gig. Tr. Prof. Zabol., Iss. 3: 25-28
- Reference Type:
- secondary source
- Title:
- Toxicity Profile, Dimethylphthalate
- Author:
- BIBRA
- Year:
- 1 987
- Bibliographic source:
- BIBRA
Materials and methods
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl phthalate
- EC Number:
- 205-011-6
- EC Name:
- Dimethyl phthalate
- Cas Number:
- 131-11-3
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 1,2-dimethyl benzene-1,2-dicarboxylate
- Test material form:
- liquid
Constituent 1
- Specific details on test material used for the study:
- Dimethyl phthalate;
purity not specified
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: no data
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- daily, 4 hours/day
Doses / concentrationsopen allclose all
- Dose / conc.:
- 0.7 mg/m³ air
- Remarks:
- 0.7 - 1.8 ug/l
- Dose / conc.:
- 1.8 mg/m³ air
- Remarks:
- 0.7 - 1.8 ug/l
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- dose level:
- Effect level:
- ca. 0.7 - < 1.8 mg/m³ air (nominal)
- Sex:
- not specified
- Basis for effect level:
- other: function of nervous system, liver and kidney.
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
There were changes in respiratory rate, in blood cells, in the liver and kidneys and in the function of the nervous system observed. No further details on the nature of effects, severity, control data, or performed observation.
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
