Registration Dossier
Registration Dossier
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EC number: 205-011-6 | CAS number: 131-11-3
Repeated dose toxicity: other routes
Administrative data
- Endpoint:
- sub-chronic toxicity: other route
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract/table available
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A Toxicological Investigation of Some Acute, Short-Term, and Chronic Effects of Administering Di-2-Ethylhexyl Phthalate (DEHP) and Other Phthalate Esters'
- Author:
- Lawrence WH et al.
- Year:
- 1 975
- Bibliographic source:
- Environ. Res. 9: 1-11
- Reference Type:
- secondary source
- Title:
- No information
- Author:
- ECB-IUCLID
- Year:
- 2 000
- Bibliographic source:
- European Chemicals Bureau, 11-FEB-2000
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- no
Test material
- Reference substance name:
- Dimethyl phthalate
- EC Number:
- 205-011-6
- EC Name:
- Dimethyl phthalate
- Cas Number:
- 131-11-3
- Molecular formula:
- C10H10O4
- IUPAC Name:
- 1,2-dimethyl benzene-1,2-dicarboxylate
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- ICR
- Sex:
- male
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- not specified
- Duration of treatment / exposure:
- 18 weeks
- Frequency of treatment:
- 5 days/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
"a series of doses" (no further data)
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: no data
Results and discussion
Effect levels
- Dose descriptor:
- other: chronic LD50
- Effect level:
- ca. 1 400 other: mg/kg (1.18 mL/kg)
Any other information on results incl. tables
The chronic LD50 was ca. 1400 mg/kg (1.18 ml/kg).
A constant value was reached after 18 weeks.
Applicant's summary and conclusion
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