Registration Dossier
Registration Dossier
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EC number: 201-254-7 | CAS number: 80-15-9
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: collection of data
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 975
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Eye irritation was tested on rabbit. The test substance was instilled undiluted or in propylene glycol.
- GLP compliance:
- no
Test material
- Reference substance name:
- α,α-dimethylbenzyl hydroperoxide
- EC Number:
- 201-254-7
- EC Name:
- α,α-dimethylbenzyl hydroperoxide
- Cas Number:
- 80-15-9
- Molecular formula:
- C9H12O2
- IUPAC Name:
- 1-methyl-1-phenylethyl hydroperoxide
- Details on test material:
- no data
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- not specified
Test system
- Vehicle:
- other: undiluted or diluted in propylene glycol
- Controls:
- not specified
- Duration of treatment / exposure:
- 24 h
- Observation period (in vivo):
- 24 h
- Number of animals or in vitro replicates:
- 5
Results and discussion
Any other information on results incl. tables
0.005 ml undiluted chemical: severe corneal injury with iritis and necroid eylids; 5% solution: moderate corneal injury with iritis; 1% solution: no corneal injury
Overall evaluation: Grade 9, severe
Applicant's summary and conclusion
- Conclusions:
- Cumene hydroperoxyde caused severe eye irritation
- Executive summary:
Cumene hydroperoxide was tested for eye irritation in rabbits; instillation of small amounts of undiluted substance caused severe eye irritation with corneal injury, iritis and necroid eyelids
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