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EC number: 217-164-6 | CAS number: 1760-24-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
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- Auto flammability
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- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
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- Stability: thermal, sunlight, metals
- pH
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- Endpoint summary
- Stability
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Repeated dose toxicity: dermal
Administrative data
- Endpoint:
- short-term repeated dose toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- This study was designed to determine the effects in rats resulting from repeated percutaneous exposure to A-1120 for 9 doses over an 11 day period.
- GLP compliance:
- yes
- Limit test:
- no
Test material
- Reference substance name:
- N-(3-(trimethoxysilyl)propyl)ethylenediamine
- EC Number:
- 217-164-6
- EC Name:
- N-(3-(trimethoxysilyl)propyl)ethylenediamine
- Cas Number:
- 1760-24-3
- Molecular formula:
- C8H22N2O3Si
- IUPAC Name:
- N-(3-(trimethoxysilyl)propyl)ethylenediamine
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Analytical verification of doses or concentrations:
- no
- Duration of treatment / exposure:
- 11 days
- Frequency of treatment:
- 9 applications
Doses / concentrationsopen allclose all
- Dose / conc.:
- 257.5 mg/kg bw/day (nominal)
- Dose / conc.:
- 772.5 mg/kg bw/day (nominal)
- Dose / conc.:
- 1 545 mg/kg bw/day (nominal)
- No. of animals per sex per dose:
- 20/sex/control and high dose
10/sex/ mid and low dose - Control animals:
- other: filtered water
Results and discussion
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- >= 1 545 mg/kg bw/day
- Based on:
- test mat.
- Sex:
- male/female
- Basis for effect level:
- other: No signs of systemic toxicity.
Target system / organ toxicity
- Critical effects observed:
- no
Any other information on results incl. tables
No clinical signs of toxicity except local effects on skin. Barely perceptible erythema was observed occasionally in males of the 772.5 and 1545 mg/kg bw/day groups and in females of the 1545 mg/kg bw/day group during the first week of treatment. Exfoliation and/or excoriation, were observed during the treatment period in males and females of the 772.5 and 1545 mg/kg bw/day groups. One female of the 257.5 mg/kg bw/day group also showed excoriation during the treatment period. During the 19 -day recovery period, exfoliation and/or excoriation were observed in males and females of the 1545 mg/kg bw/day group. No skin reactions were observed after day 17.
Decreases in food consumption were observed in males of the 772.5 and 1545 mg/kg bw/day during the treatment period. Some body weight decreases were observed but there was no clear dose-response. Slight increases in water consumption were observed in females of the 772.5 and 1545 mg/kg bw/day groups during the study. However, the increases were not considered to be toxicologically significant due to the lack of any associated changes in clinical pathology parameters and the small magnitude of the changes. There were no treatment-related effects on haematology, clinical chemistry, isoenzymes or urinalysis at the end of the treatment period. There was no effect on haematological parameters at the end of the recovery period.
There were slight increases in adrenal weights in the mid and high dose groups, but in light of the lack of pathological findings these were not considered to be toxicologically significant.
Various signs of skin irritation were observed. Exfoliation and excoriation were noted at the end of the treatment period of males in the mid and high dose groups, and females of all groups. Microscopic findings in these groups were hyperkeratosis, acanthosis, epidermitis and dermatitis. Ulceration and dermal fibrosis were observed occasionally in the same treated groups. Residual effects, as indicated by minimal hyperkeratosis and dermatitis were observed in males and females of the high dose group at the end of the 19 -day recovery period.
Applicant's summary and conclusion
- Conclusions:
- Treatment of rats to N-(3-(trimethoxysilyl)propyl)ethylenediamine for nine cutaneous applications during an 11-day period produced transient clinical, necropsy and microscopic observations indicative of mild to moderate skin irritation in males treated with 772.5 and 1545 mg/kg bw/day and females treated with 257.5 mg/kg bw/day and above. There was no clear indication of systemic toxicity. Therefore the NOAEL for systemic effects is at least 1545 mg/kg bw/day in rats.
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