Registration Dossier
Registration Dossier
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EC number: 236-068-5 | CAS number: 13138-45-9
Endpoint summary
Administrative data
Description of key information
Value used for CSA: irritating (skin)
Value used for CSA: serious eye damage (eye)
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irreversible damage)
Additional information
In the OECD Guideline 404 (Acute Dermal Irritation / Corrosion) tests in rabbits, nickel nitrate was a skin irritant. Based on this data, classification as Skin Irrit. 2: H315 is warranted.
In the OECD Guideline 405 (Acute Eye Irritation / Corrosion) tests in rabbits, nickel nitrate causes serious eye damage and the effects were not reversible within the 21-day observation period. Based on this data, classification as Eye Dam.1; H318 is warranted.
The following information is taken into account for any hazard / risk assessment:
Skin: The skin irritation potential has been examined in studies performed by the OECD Guideline 404 (Acute Dermal Irritation / Corrosion) demonstrated nickel nitrate is a skin irritant.
Eye: The eye irritation potential has been examined in studies performed by the OECD Guideline 405 (Acute Eye Irritation / Corrosion) demonstrated nickel nitrate results in serious eye damage.
Value used for CSA:
Skin irritation / corrosion: irritating
Eye irritation: serious (irreversible) eye damage
Justification for classification or non-classification
Ni nitrate is classified as Skin Irrit. 2: H315 in the 1st ATP to the CLP Regulation. It is also classified as Eye Dam.1; H318. Background information regarding these classification has been provided in the discussion section above.
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