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Long-term toxicity to aquatic invertebrates

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Description of key information

The substance is with high probability not chronically harmful to aquatic invertebrates.
No long-term effects occurred for Daphnia magna (OECD 211) in the range of water solubility; NOEL (21d) >= 2 mg/L (based on the Loading rate of a WAF)

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Additional information

The long-term toxicity on aquatic invertebrates was investigated with the waterflea Daphnia magna, in a GLP guideline study according to OECD 211 [BMG, 2013].  Since the test item is a substance that is only partially soluble, the test solution was prepared as water accommodated fraction (WAF), with a loading rate of 2 mg/L. During the three weeks test duration a geometric mean concentration of 1.42 µg/L was measured.

The first appearance of living offspring was observed between day 8 and 12 at the loading rate of 2.0 mg/L and in the blank control. No effects on the offspring were determined during the 21 days test duration. Therefore, the no observed effect loading (NOEL) was >= 2.0 mg/L.