Registration Dossier

Administrative data

Description of key information

not neurotoxic to the domestic fowl

Key value for chemical safety assessment

Effect on neurotoxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
NOAEL
6 000 mg/kg bw/day

Effect on neurotoxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Effect on neurotoxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

The substance was applied to a total of 50 hens of the White Leghorn strain. The treatment by gavage was performed twice at an interval of 21 days with doses of 2150 (20 hens) and 6000 mg/kg bw (30 hens).

Neither acute nor delayed toxic symptoms were recorded during the 50-day observation period. Histopathological lesions of the nervous system were absent and there was no evidence for delayed neurotoxicity.

Justification for classification or non-classification

There are conclusive but not sufficient data for classification of the test substance with regard to neurotoxicity. The substance is not classified for this endpoint in accordance to the CLP Regulation (EC) No 1272/2008.