Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 231-152-8 | CAS number: 7440-43-9
Endpoint summary
Administrative data
Description of key information
Limited information is available on the skin, eye and respiratory tract irritation potential of cadmium metal and cadmium compounds. In a study on patients with eczema, cadmium chloride caused skin irritation in 1.7% of the volunteers when applied at 2%. Based on single and repeated inhalation exposure studies, cadmium oxide fumes may be considered irritating to the respiratory tract. However, given the carcinogenic properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place at the workplace to prevent contact.Therefore, neither skin, eye nor respiratory tract irritation are expected to be an issue for human health and further testing is not considered necessary for these endpoints, in accordance with Annex XI (3) of the REACH directive. This is in line with the conclusions of the EU RAR (ECB, 2007).
No studies were located regarding corrosivity for humans or animals.However, if at all, significantexposure is expected to occur principally in occupational settings.Given the carcinogen properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place to prevent contact.Therefore, corrosivity is not expected to be an issue for human health and further testing is not considered necessary, in accordance withAnnex XI (3) of the REACH directive.This is in line with the conclusions of the EU RAR (ECB, 2007).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Additional information
Limited information is available on the skin, eye and respiratory tract irritation potential of cadmium metal and cadmium compounds. In a study on patients with eczema, cadmium chloride caused skin irritation in 1.7% of the volunteers when applied at 2%. Based on single and repeated inhalation exposure studies, cadmium oxide fumes may be considered irritating to the respiratory tract. However, given the carcinogenic properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place at the workplace to prevent contact.Therefore, neither skin, eye nor respiratory tract irritation are expected to be an issue for human health and further testing is not considered necessary for these endpoints, in accordance with Annex XI (3) of the REACH directive. This is in line with the conclusions of the EU RAR (ECB, 2007).
At present, none of the cadmium substances covered in the present assessment is classified for irritation according to Directive 67/548/EEC.
No studies were located regarding corrosivity for humans or animals.However, if at all, significantexposure is expected to occur principally in occupational settings.Given the carcinogen properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place to prevent contact.Therefore, corrosivity is not expected to be an issue for human health and further testing is not considered necessary, in accordance withAnnex XI (3) of the REACH directive.This is in line with the conclusions of the EU RAR (ECB, 2007).
At present, none of the cadmium substances covered in the present assessment is classified for corrosivity in Annex I of Directive 67/548/EEC.
Justification for classification or non-classification
Limited information is available on the skin, eye and respiratory tract irritation potential of cadmium metal and cadmium compounds. However, given the carcinogenic properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place at the workplace to prevent contact.Therefore, neither skin, eye nor respiratory tract irritation are expected to be an issue for human health and further testing is not considered necessary for these endpoints, in accordance with Annex XI (3) of the REACH directive. This is in line with the conclusions of the EU RAR (ECB, 2007).
At present, none of the cadmium substances covered in the present assessment is classified for irritation according to Directive 67/548/EEC.
No studies were located regarding corrosivity for humans or animals.However, if at all, significantexposure is expected to occur principally in occupational settings.Given the carcinogen properties of cadmium metal and some of the cadmium compounds, risk reduction measures are in place to prevent contact.Therefore, corrosivity is not expected to be an issue for human health and further testing is not considered necessary, in accordance with Annex XI (3) of the REACH directive.This is in line with the conclusions of the EU RAR (ECB, 2007).
At present, none of the cadmium substances covered in the present assessment is classified for corrosivity in Annex I of Directive 67/548/EEC.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
