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Toxicological information

Direct observations: clinical cases, poisoning incidents and other

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Administrative data

Endpoint:
direct observations: clinical cases, poisoning incidents and other
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Test procedure in accordance with generally accepted scientific principles and described in sufficient detail

Data source

Reference
Reference Type:
publication
Title:
Aromatic amines in occupational environment and in biological samples.
Author:
Rimatori V and Castellino N
Year:
1989
Bibliographic source:
J Univ Occup Environ Health Suppl 11: 699-705

Materials and methods

Study type:
other: biomonitoring workers
Endpoint addressed:
not applicable
Principles of method if other than guideline:
other: biomonitoring

Test material

Constituent 1
Chemical structure
Reference substance name:
N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
EC Number:
212-344-0
EC Name:
N-1,3-dimethylbutyl-N'-phenyl-p-phenylenediamine
Cas Number:
793-24-8
Molecular formula:
C18H24N2
IUPAC Name:
N-(1,3-dimethylbutyl)-N'-phenylbenzene-1,4-diamine

Method

Route of exposure:
inhalation
Reason of exposure:
unintentional, occupational
Exposure assessment:
measured

Results and discussion

Any other information on results incl. tables

RS-Freetext:
In the rubber industry 6PPD was detected in the urine of
6PPD exposed workers. In environmental air levels were in
the range of < 0.01 - 260 µg/mc (peak 6600) and in urine
levels were in the range of < 1 - 300 µg/g creatinine (peak
580). The samples were collected between 1982 and 1987.

Applicant's summary and conclusion