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Toxicological information

Acute Toxicity: other routes

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Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment (test predominantly on effects on cadmium toxicity)

Data source

Reference
Reference Type:
publication
Title:
Effect of the chelating agent sodium tripolyphosphate on cadmium toxicity in mice
Author:
Andersen O, Hägerstrand I and Nordberk GF
Year:
1982
Bibliographic source:
Environmental research 29: 54-61

Materials and methods

Test guideline
Qualifier:
no guideline followed
Principles of method if other than guideline:
Effects of sodium tripolyphosphate on cadmium toxicity administered subcutaneously were studied.
Animals were administered 30µmole/kg cadmium, 30µmole/kg CD + 90µmole STTP and 90µmole/kg STPP
Animals given STTP alone were sacrificed 24h post administration and the liver prepared for histological evaluation.
GLP compliance:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
Pentasodium triphosphate
EC Number:
231-838-7
EC Name:
Pentasodium triphosphate
Cas Number:
7758-29-4
Molecular formula:
H5O10P3.5Na
IUPAC Name:
pentasodium triphosphate
Details on test material:
- Name of test material (as cited in study report): Sodium tripolyphosphate (STPP)

Test animals

Species:
mouse
Strain:
CBA
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source:
- Age at study initiation: 3-4 months
- Weight at study initiation: 30.0-34.9g
- Housing:Plastic cages
- Diet: Rostock mixture rat pellets ad libitum
- Water: ad libitum

Administration / exposure

Route of administration:
subcutaneous
Vehicle:
other: 0.9% NaCl
Doses:
90µmole/kg
No. of animals per sex per dose:
6 STPP
10 Cd + STPP
Control animals:
no
Statistics:
Student's t test

Results and discussion

Mortality:
7/10 animals receiving 30µmole/kg Cd + 90µmole/mg STPP
0/6 animals receiving 90µmole/kg STPP
Gross pathology:
All animals had normal livers

Any other information on results incl. tables

No effects were reported at 90µmole/kg

Animals treated with cadmium and STPP suffered greater effects than animals administered with cadmium alone or STPP alone.

Applicant's summary and conclusion