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EC number: 231-838-7 | CAS number: 7758-29-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Documentation insufficient for assessment (test predominantly on effects on cadmium toxicity)
Data source
Reference
- Reference Type:
- publication
- Title:
- Effect of the chelating agent sodium tripolyphosphate on cadmium toxicity in mice
- Author:
- Andersen O, Hägerstrand I and Nordberk GF
- Year:
- 1 982
- Bibliographic source:
- Environmental research 29: 54-61
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Effects of sodium tripolyphosphate on cadmium toxicity administered subcutaneously were studied.
Animals were administered 30µmole/kg cadmium, 30µmole/kg CD + 90µmole STTP and 90µmole/kg STPP
Animals given STTP alone were sacrificed 24h post administration and the liver prepared for histological evaluation. - GLP compliance:
- not specified
Test material
- Reference substance name:
- Pentasodium triphosphate
- EC Number:
- 231-838-7
- EC Name:
- Pentasodium triphosphate
- Cas Number:
- 7758-29-4
- Molecular formula:
- H5O10P3.5Na
- IUPAC Name:
- pentasodium bis(phosphonatooxy)phosphinate
- Details on test material:
- - Name of test material (as cited in study report): Sodium tripolyphosphate (STPP)
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CBA
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:
- Age at study initiation: 3-4 months
- Weight at study initiation: 30.0-34.9g
- Housing:Plastic cages
- Diet: Rostock mixture rat pellets ad libitum
- Water: ad libitum
Administration / exposure
- Route of administration:
- subcutaneous
- Vehicle:
- other: 0.9% NaCl
- Doses:
- 90µmole/kg
- No. of animals per sex per dose:
- 6 STPP
10 Cd + STPP - Control animals:
- no
- Statistics:
- Student's t test
Results and discussion
- Mortality:
- 7/10 animals receiving 30µmole/kg Cd + 90µmole/mg STPP
0/6 animals receiving 90µmole/kg STPP - Gross pathology:
- All animals had normal livers
Any other information on results incl. tables
No effects were reported at 90µmole/kg
Animals treated with cadmium and STPP suffered greater effects than animals administered with cadmium alone or STPP alone.
Applicant's summary and conclusion
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