Registration Dossier
Registration Dossier
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EC number: 282-758-4 | CAS number: 84402-58-4
Eye irritation
Administrative data
- Endpoint:
- eye irritation, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1983-08-18 till 1983-08-29
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline study without GLP.
- Justification for type of information:
- QSAR and in-vitro methods not available at that time.
QSAR not applicable for organic salt compound MPAAU.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 983
- Report date:
- 1983
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Version / remarks:
- May 12, 1981
- Deviations:
- no
- GLP compliance:
- no
Test material
- Reference substance name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- EC Number:
- 282-758-4
- EC Name:
- Methylphosphonic acid, compound with amidinourea (1:1)
- Cas Number:
- 84402-58-4
- Molecular formula:
- C2H6N4O.CH5O3P
- IUPAC Name:
- Phosphonic acid, P-methyl-, compd. with N-(aminoiminomethyl)urea (1:1)
- Details on test material:
- Technical product
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the left eye of the test animals remained untreated
- Amount / concentration applied:
- 0.1 ml of the test item was placed into the conjunctival sac of the right eye of each animal.
- Number of animals or in vitro replicates:
- 3 animals
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- other: 1h, 24h, 48h, 72h, 7 days
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- other: no effect
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- other: 1 h
- Score:
- 1
- Max. score:
- 1
- Reversibility:
- fully reversible within: 24 h
- Irritant / corrosive response data:
- not irritating
- Other effects:
- The body weight in 2 animals was decreased during the test period.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The test item is non irritant and not corrosive when applied to the rabbit eye mucosa.
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