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Diss Factsheets
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EC number: 231-302-2 | CAS number: 7488-55-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://chesar.echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no glp, no guideline a available (older than guideline and glp)
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Primary activity was measured by the amount of 14C uptake by algae over a 48h periode. The concentration causing a 50% reduction in productivity (median inhibition activity, IC 50) was estimated.
The effect of tin on reproduction (growth) was measured spectrophotometrically. One ml of the incolum was added to 49 k CHU-10 medium with and without tin compounds. - GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- no
- Test organisms (species):
- other: scendesmus quadricauda
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Remarks on exposure duration:
- see table
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: dissolved Sn
- Basis for effect:
- other: 14C uptake
- Duration:
- 4 h
- Dose descriptor:
- EC50
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: dissolved Sn
- Basis for effect:
- cell number
- Duration:
- 4 h
- Dose descriptor:
- EC50
- Effect conc.:
- 50 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: dissolved Sn
- Basis for effect:
- cell number
- Duration:
- 4 h
- Dose descriptor:
- EC50
- Effect conc.:
- 12 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: dissolved Sn
- Basis for effect:
- cell number
- Duration:
- 8 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 14 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Remarks:
- Sn
- Basis for effect:
- growth rate
- Validity criteria fulfilled:
- yes
- Conclusions:
- NOEC (Reproduction) = 12 mg Sn/ L = 21.7 mg SnSO_4 7 l (stabilisation with humic acid instead of EDTA); measurement of Sn total
- Endpoint:
- toxicity to aquatic algae and cyanobacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1997
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: no glp, good documentation
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- The cyanobacterium was exposed to tin compounds in the liquid modified medium Z (with lowered phosphate and bicarbonate contents by 50% compared to the original cultivation medium), of initial pH 7.2, or (dependent on the experiment) buffered with 10 nM Hpes/NaOH and adjusted to an appropriate pH value (7-9).
Inorganic tin was used in the forms of stannous (SnCl_2 x 2H_2O) and stannic chlorides(SnCL_4 x 5H_2o) in the range 1-10 mg Sn/L. The stock solution of humic acid was added to the cyanobacterium cultures to the final concentration of 20 mg/KL. The solution of metal and humic acid ware prepared separately and sterilized by passing through membrane filters (0.45 µm).
Growth of the cyanobaterium cultures was recorded by measuring the optical density at 650 nm and chlorophyll a content.
All experiments were carried out at least in triplicate at 23°C in an illumination regime: 16h light / 8h dark. - GLP compliance:
- no
- Analytical monitoring:
- yes
- Vehicle:
- yes
- Test organisms (species):
- other: synechocystis aquatilis
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 96 h
- Duration:
- 96 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 5 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: Sn(II)
- Basis for effect:
- growth rate
- Remarks on result:
- other: pH 7.2
- Duration:
- 96 h
- Dose descriptor:
- EC50
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- other: Sn(II)
- Basis for effect:
- growth rate
- Remarks on result:
- other: pH 7.2
- Validity criteria fulfilled:
- yes
- Conclusions:
- NOEC SnSO_4 = 9.1. mg/L
EC50 SnSO_4 = 18.2 mg/L
Referenceopen allclose all
Description of key information
Key value for chemical safety assessment
- EC50 for freshwater algae:
- 18.2 mg/L
- EC10 or NOEC for freshwater algae:
- 9.1 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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