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Reference
Endpoint:
activated sludge respiration inhibition testing
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2001
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: study according to guideline, glp
Qualifier:
according to guideline
Guideline:
OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
inisterium für Arbeit, Integration und Soziales des Landes Nordrhein Westfalen, Düsseldorf, Germany
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
activated sludge of a predominantly domestic sewage
Test type:
semi-static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
3 h
Duration:
3 h
Dose descriptor:
EC50
Effect conc.:
1 194 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate
Duration:
3 h
Dose descriptor:
EC10
Effect conc.:
834 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
inhibition of total respiration
Remarks:
respiration rate

Table 1: Inhibition (%) of the respiration rate by the test substance

Test concentration

62.5 mg/L

125 mg/L

250 mg/L

500 mg/L

1000 mg/L

-7.9 %

8.5 %

-3.4 %

-12.5 %

26.4 %

Table 2: pH in the test vessels at test start and test end

Vessel

 

C1

T1

T2

T3

T4

T5

AC

C2

RI1

RI2

RI3

start

7.3

7.5

7.3

8.0

7.6

7.8

7.4

7.4

7.3

7.3

7.3

end

8.5

8.3

8.3

8.4

8.3

8.2

7.9

8.4

8.4

8.3

8.5

Validity criteria fulfilled:
yes
Conclusions:
The EC-values were found to be EC10 = 834 mg/L, EC20 = 943 mg/L, and EC50 = 1194 mg/L

Description of key information

OECD 209, The EC-values were found to be EC10 = 834 mg/L, EC20 = 943 mg/L, and EC50 = 1194 mg/L

Key value for chemical safety assessment

EC50 for microorganisms:
1 194 mg/L
EC10 or NOEC for microorganisms:
834 mg/L

Additional information

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