Registration Dossier
Registration Dossier
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EC number: 220-552-8 | CAS number: 2809-21-4
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 18.04.1989 to 25.04.1989
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only a summary report was available for review.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Etidronic acid
- EC Number:
- 220-552-8
- EC Name:
- Etidronic acid
- Cas Number:
- 2809-21-4
- Molecular formula:
- C2H8O7P2
- IUPAC Name:
- (1-hydroxyethane-1,1-diyl)bis(phosphonic acid)
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: No data
- Age at study initiation: No data
- Weight at study initiation: 2-4 kg
- Housing: Individually in cages (no further details)
- Diet (e.g. ad libitum): Ad libitum
- Water (e.g. ad libitum): Ad libitum
- Acclimation period: No data
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 18± 2
- Humidity (%): No data
- Air changes (per hr): No data
- Photoperiod (hrs dark / hrs light): No data
IN-LIFE DATES: From: 18.04.1989 To: 25.04.1989
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- other: intact depilated skin and scarified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24 hours, 72 hours and 7 days
- Number of animals:
- No data
- Details on study design:
- TEST SITE
- Area of exposure: No data
- % coverage: No data
- Type of wrap if used: No data
REMOVAL OF TEST SUBSTANCE
- Washing (if done): No data
- Time after start of exposure: No data
SCORING SYSTEM: No data
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: all time points
- Score:
- 0
- Max. score:
- 8
- Remarks on result:
- other: No signs of irritation observed.
- Irritant / corrosive response data:
- No erythema or swelling was observed at any time point.
- Other effects:
- None reported.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In a summary of a skin irritation/corrosion study report (reliability score 4) HEDP was not irritating to the skin of rabbits following a 24 hour exposure.
- Executive summary:
In a summary of a skin irritation/corrosion study report (reliability score 4) HEDP was not irritating to the skin of rabbits following a 24 hour exposure.
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