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Ecotoxicological information

Toxicity to microorganisms

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Administrative data

Link to relevant study record(s)

Description of key information

EC10 (3 h) of > 1000 mg/L (OECD 209)
NOEC (28 d) of ≥ 100 mg/L (OECD 301C)

Key value for chemical safety assessment

Additional information

Since no studies investigating the toxicity of fatty acids, coco, isotridecyl esters (CAS 91031-91-3) to microorganisms are available for this endpoint, in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5 a read across to the structurally most similar category members tetradecyl myristate (CAS 3234-85-3) and Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was conducted. This read-across is justified in detail in the overall summary (IUCLID chapter 6.1) and within the category justification in IUCLID Section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was used for the assessment. The read-across substance Tetradecyl myristate is covering the upper end, whereas the read-across substance Fatty acids, C8 - 10, C12 - 18-alkyl esters covers the lower end of fatty acid and fatty alcohol chain lengths. The available data allow interpolation to fatty acids, coco, isotridecyl esters. As it can be seen in the data matrix of the category justification in section 13 and the overall summary, all reliable data in the category support the hazard assessment of each category member by showing a consistent pattern of results.

The toxicity of the read-across substance tetradecyl myristate (CAS 3234-85-3) to activated sludge microorganisms was investigated in a biodegradation study according to OECD 301C under GLP conditions (Ministry of Economy, Trade and Industry, Japan, 1992). A test concentration of 100 mg/L (nominal) did not inhibit the biodegradation process of the test substance. Therefore, the test substance is not toxic to activated sludge microorganisms and the test concentration can be used as a NOEC value for the toxicity to activated sludge microorganisms. Thus, a NOEC (28 d) of ≥ 100 mg/L resulted.

The second study with the read-across substance Fatty acids, C8 - 10, C12 - 18-alkyl esters (CAS 95912-86-0) was performed according to OECD 209 under GLP conditions (Hammer, 2013). Activated sludge microorganisms were exposed to the test substance up to a nominal concentration of 1000 mg/L. No effects were observed based on the respiration rate after 3 h of incubation resulting in an EC10 (3 h) of > 1000 mg/L. An increase of respiration was recorded in all treatments compared to the control values.

Based on the results from two structurally related read-across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) which are characterized by a similar ecotoxicological profile and comparable structure, it can be concluded that fatty acids, coco, isotridecyl esters will not exhibit effects on activated sludge microorganisms.