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Toxicological information

Toxicity to reproduction: other studies

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Administrative data

Endpoint:
toxicity to reproduction: other studies
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Meets generally accepted scientific standards, well documented and acceptable for assessment

Data source

Referenceopen allclose all

Reference Type:
publication
Title:
Safety of the metal scavengers sodium metasilicate and sodium polyphosphate.
Author:
Saiwai K et al.
Year:
1980
Bibliographic source:
Internal Report Toho University
Reference Type:
secondary source
Title:
Soluble Silicates. CAS No. 1344-09-8, 6834-92-0, 10213-79-3, 13517-24-3 and 1312-76-1.
Author:
OECD SIDS
Year:
2004

Materials and methods

Principles of method if other than guideline:
Type: other: male and female reproduction organs
GLP compliance:
no
Type of method:
in vivo

Test material

Constituent 1
Chemical structure
Reference substance name:
Disodium metasilicate
EC Number:
229-912-9
EC Name:
Disodium metasilicate
Cas Number:
6834-92-0
Molecular formula:
H2O3Si.2Na Soluble Silicates Category
IUPAC Name:
disodium oxosilanediolate

Test animals

Species:
mouse
Strain:
other: ddy-SLC
Sex:
male/female

Administration / exposure

Route of administration:
oral: drinking water
Vehicle:
water
Analytical verification of doses or concentrations:
no
Duration of treatment / exposure:
3 months
Frequency of treatment:
ad libitum
Duration of test:
3 months
Doses / concentrations
Remarks:
Doses / Concentrations:
300, 900, 2700 ppm (males), 333, 1000, 3000 ppm (females)
Basis:

Control animals:
yes, concurrent vehicle

Results and discussion

Effect levels

open allclose all
Dose descriptor:
NOAEL
Effect level:
> 2 700 ppm
Sex:
male
Dose descriptor:
NOAEL
Effect level:
> 3 000 ppm
Sex:
female

Any other information on results incl. tables

No effects on reproductive organs upon microscopic examination and wet weight determination.

Applicant's summary and conclusion