Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: inhalation

Currently viewing:

Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
other information
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
Internal test method in accordance with Smyth HF et al., Am Ind Hyg Ass J 23: 95-107 (1962)
GLP compliance:
no
Test type:
other: Inhalation Risk Test

Test material

Constituent 1
Chemical structure
Reference substance name:
2,6-dimethylmorpholine
EC Number:
205-509-3
EC Name:
2,6-dimethylmorpholine
Cas Number:
141-91-3
Molecular formula:
C6H13NO
IUPAC Name:
2,6-dimethylmorpholine

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
air
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
1h: 22.25 mg/l;
3h: 22.66 mg/l;
7h: 20.14 mg/l;
(Nominal concentrations. No analytical verification of test atmosphere concentrations).
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: Inhalation Risk Test
Effect level:
other: Inhalation Risk Test
Based on:
test mat.
Exp. duration:
1 h
Remarks on result:
other: Inhalation period of a vapour-air-mixture causing no mortality was determined.
Mortality:
1 h: 0/6
3 h: 3/6
7 h: 4/6
Clinical signs:
other: Symptoms resulted probably from the corrosive effects of the substance: escape attempts, eyelid closure, dyspnea, loss of pain reflex, tremor, irregular gait, scrubby fur. In one animal of the 7 h exposure corrosions at the nose could be observed.
Body weight:
no data
Gross pathology:
Heart: acute dilatation of the ventricle; acute congestion;
Lung: acute moderate distensions

Any other information on results incl. tables

The inhalation of a highly saturated vapor-air-mixture caused mortality after 3 h of exposure. There is indication that the test substance causes local irritation to exposed tissues.

Applicant's summary and conclusion

Interpretation of results:
study cannot be used for classification