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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented study report which meets basic scientific principles

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1981
Report date:
1981

Materials and methods

Principles of method if other than guideline:
BASF-Test in accordance with Smyth HF et al., Am Ind Hyg Ass J 23: 95-107 (1962)
GLP compliance:
no
Test type:
other: Inhalation Risk Test

Test material

Constituent 1
Reference substance name:
Automatically generated during migration to IUCLID 6, no data available
IUPAC Name:
Automatically generated during migration to IUCLID 6, no data available
Details on test material:
- Name of test material (as cited in study report): 2,6 - Dimethyl-morpholin (75 % cis/25 % trans)
- Physical state: liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
male/female

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
other: unchanged (no vehicle)
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
7 h
Concentrations:
1h: 22.25 mg/l;
3h: 22.66 mg/l;
7h: 20.14 mg/l;
(Nominal concentrations. No analytical verification of test atmosphere concentrations).
No. of animals per sex per dose:
3
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of exposure and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
other: Inhalation Risk Test
Effect level:
other: Inhalation Risk Test
Exp. duration:
1 h
Remarks on result:
other: Additional exposure duration: 3 h, 7 h
Mortality:
1 h: 0/6
3 h: 3/6
7 h: 4/6
Clinical signs:
other: Symptoms resulted probably from the corrosive effects of the substance: escape attempts, eyelid closure, dyspnea, loss of pain reflex, tremor, irregular gait, scrubby fur. In one animal of the 7 h exposure corrosions at the nose could be observed.
Body weight:
no data
Gross pathology:
Heart: acute dilatation of the ventricle; acute congestion;
Lung: acute moderate distensions;

Any other information on results incl. tables

The inhalation of a highly saturated vapor-air-mixture caused mortality after 3 h of exposure. There is indication that the test substance causes local irritation to exposed tissues.

Applicant's summary and conclusion