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Administrative data

Endpoint:
surface tension
Type of information:
experimental study
Adequacy of study:
key study
Study period:
02 June 2015-18 August 2015
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: GLP-compliant study in accordance with EC A.5 and OECD 115.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2015
Report date:
2015

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
EU Method A.5 (Surface Tension)
Version / remarks:
(2008)
Deviations:
no
Qualifier:
according to guideline
Guideline:
OECD Guideline 115 (Surface Tension of Aqueous Solutions)
Version / remarks:
(1995)
Deviations:
no
GLP compliance:
yes
Type of method:
OECD harmonised ring method

Test material

Constituent 1
Chemical structure
Reference substance name:
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
EC Number:
608-945-6
Cas Number:
340-90-9
Molecular formula:
C13H11NO6
IUPAC Name:
(2S)-2-(1,3-DIOXO-2,3-DIHYDRO-1H-ISOINDOL-2-YL)PENTANEDIOIC ACID
Test material form:
solid: particulate/powder
Remarks:
migrated information: powder
Details on test material:
- Name (as cited in study report): Phthalyl-L-Glu
- Appearance: white powder
- Storage conditions: room temperature

Results and discussion

Surface tension
Surface tension:
72.4 mN/m
Temp.:
20 °C
Conc.:
1 g/L

Any other information on results incl. tables

Table: Surface tension measurements

 

Measurement

Time passed after transfer test solution to test vessel
[minutes]

Surface tension [mN/m]

individual

mean (1)

mean (2)

 

 

 

 

 

1

16

72.4

 

 

2

17

71.6

71.7

72.4

3

18

71.7

 

 

4

19

71.8

 

 

5

20

71.6

 

 

6

21

71.7

 

 

 

 

 

 

 

(1) The result of measurement 1 was significantly higher than 2 – 6. Measurements 2 – 6 were within 0.5 mN/m. The mean surface tension was, therefore, calculated from measurements 2 to 6, after equilibrium was reached.

(2) Multiplied by the calibration factor. A correction according to Harkins-Jordan was not required.

Applicant's summary and conclusion

Conclusions:
In a GLP-compliant study in accordance with EC A.5 and OECD 115 using the OECD harmonized ring method, the surface tension at 20°C of a 1 g/L aqueous solution of Phthalyl-L-Glu has been determined as 72.4 mN/m. Phthalyl-L-Glu is not surface active according to the criterium in the EC A.5 guideline.