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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

LD50 (oral,rat): ca. 5000 mg/kg bw

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
5 000 mg/kg bw

Acute toxicity: via inhalation route

Endpoint conclusion
Endpoint conclusion:
no study available

Acute toxicity: via dermal route

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

In an acute toxicity study (similar to OECD 401) conducted by BASF AG (1987) groups of 10 rats were administered doses of 1470, 3160 and 5000 mg/kg bw by gavage and observed for 14 days for lethality and clinical signs of intoxication. The mortality rate was 0/10, 1/10 and 5/10 in the low, mid and high dose groups, respectively. Clinical symptoms at 3160 mg/kg bw was dyspnea, apathy, staggering, red-brown urine, piloerection and poor general state; these symptoms were observed until day 2 or 3. At 5000 mg/kg bw dyspnea, apathy, staggering, tremors, red-brown urine, piloerection and poor general state; these symptoms were observed until 5 hours after dosing (tremors) or even until day 1, 2 or 3. The LD50 was found to be approx. 5000 mg/kg bw.


Justification for selection of acute toxicity – oral endpoint
only available study

Justification for classification or non-classification

No need for classification according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.