Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 210-276-6 | CAS number: 611-71-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
The substance ChiPros (R) – mandelic acid was tested for its mutagenic potential in bacterial strains, i.e. Salmonella typhimurlium TA 1535, TA 100, TA 1537 and TA 98 and E. coli WP2 uvrA in a standard plate test (SPT) and preincubation test (PIT) with and without metabolic activation.
The dose range was 20 - 5000 µg/plate (SPT) and 4 – 2500 µg/pate (PIT). No precipitation of the test substance was found. A bacteriotoxic effeet was observed under all test conditions. An increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S-9 mix or after the addition of a metabolizing system. According to the results of the present study, the test substance ChiPros (R) –mandelic acid is not mutagenic in the Salmonella Typhimurium / Escherichia coli reverse mutation assay under the experimental conditions chosen here.[BASF, 2002]
Justification for selection of genetic toxicity endpoint
Only one study available
Short description of key information:
Ames (ChiPros (R)-mandelic acid): negative
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No need for classification according to the EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
