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EC number: 263-731-6
CAS number: 62780-89-6
The NOAEL of 100 mg/kg/day in 28 -day repeated dose toxicity study (oral
route, OECD 407; Braun, 2008) was used to derive a DNEL long-term,
systemic effects via the inhalation route (most sensitive
endpoint/lowest NOAEL). After route-to-route extrapolation from oral to
inhalation, the dose descriptor starting point NOAEC is 88.16 mg/m³ =
100 mg/kg/d x 1/0.38 m³/kg/d x 0.67 x 0.5. This correction factor is
derived from the inhaled volumes in 8 hours under respective conditions
(6.7 m³ for base level, 10m³ for light activity). An additional
correction factor of 0.5 is used as it is assumed that the
bioavailability after oral exposure is 50% while the bioavailability
after inhalation is assumed to be 100%.
The NOAEL of 100 mg/kg/day established in the 28 -day repeated dose
toxicity study (oral route, OECD 407; Braun, 2008) was used to derive a
DNEL long-term, systemic effects via dermal administration (most
sensitive endpoint/lowest NOAEL). After route-to-route extrapolation
(oral to dermal) the dose descriptor starting point is 100 mg/kg/d. No
additional correction factor is applied as bioavailability after oral
exposure as well as after dermal exposure is assumed to be 50%.
No DNEL is derived for general population as no consumer use is expected.
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